{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:14:56Z","timestamp":1791267296350,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T00:00:00Z","timestamp":1165449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,12,15]]},"abstract":"<jats:p>To date, the neurotransmitter(s) and pathways involved in cutaneous active vasodilatation are not fully understood. The purpose of this study was to determine the potential involvement of neurokinin\u20101 (NK<jats:sub>1<\/jats:sub>) receptors to active vasodilatation. Our experimental model exploited our previous findings that repeated microdialysis infusions of substance P desensitize the NK<jats:sub>1<\/jats:sub> receptors and that substance P\u2010induced vasodilatation contains a substantial nitric oxide (NO) component. Eleven subjects were equipped with four microdialysis fibres on the ventral forearm. Site 1 served as a control and received a continuous infusion of Ringer solution. Site 2 received a continuous infusion of 10 m<jats:sc>m l<\/jats:sc>\u2010NAME to inhibit NO synthase. Site 3 received a 10 \u03bc<jats:sc>m<\/jats:sc> dose of substance P to desensitize the NK<jats:sub>1<\/jats:sub> receptors prior to whole\u2010body heating. Site 4 received a 10 \u03bc<jats:sc>m<\/jats:sc> dose of substance P combined with 10 m<jats:sc>m l<\/jats:sc>\u2010NAME. Red blood cell (RBC) flux was measured via laser\u2010Doppler flowmetry, and cutaneous vascular conductance (CVC) was calculated as RBC flux\/mean arterial pressure and normalized to maximal vasodilatation via 28 m<jats:sc>m<\/jats:sc> sodium nitroprusside. Substance P was infused for 15 min at 4 \u03bcl min<jats:sup>\u22121<\/jats:sup> in sites 3 and 4, and skin blood flow was allowed to return to baseline (\u223c45\u201360 min). Subjects then underwent a period of whole\u2010body heat stress to raise oral temperature 0.8\u20131.0\u00b0C above baseline. Pretreatment with substance P increased CVC to 48 \u00b1 2% CVC<jats:sub>max<\/jats:sub>, which was significantly greater than for sites pretreated with substance P combined with <jats:sc>l<\/jats:sc>\u2010NAME (27 \u00b1 2% CVC<jats:sub>max<\/jats:sub>; <jats:italic>P<\/jats:italic> &lt; 0.001). During whole\u2010body heating, CVC in control sites increased to 69 \u00b1 3% CVC<jats:sub>max<\/jats:sub>. Sites pretreated with substance P (48 \u00b1 3% CVC<jats:sub>max<\/jats:sub>) were significantly reduced compared to control sites (<jats:italic>P<\/jats:italic> &lt; 0.001). The CVC response to whole\u2010body heat stress in <jats:sc>l<\/jats:sc>\u2010NAME sites was significantly reduced (32 \u00b1 3% CVC<jats:sub>max<\/jats:sub>; <jats:italic>P<\/jats:italic> &lt; 0.001) compared to both control sites and sites pretreated with substance P. The CVC response to whole\u2010body heating was nearly abolished in sites pretreated with substance P combined with <jats:sc>l<\/jats:sc>\u2010NAME (20 \u00b1 2% CVC<jats:sub>max<\/jats:sub>) and was significantly reduced compared to the other three sites (all <jats:italic>P<\/jats:italic> &lt; 0.001). These data suggest NK<jats:sub>1<\/jats:sub> receptors contribute to active vasodilatation and that combined NK<jats:sub>1<\/jats:sub> receptor desensitization and NO synthase inhibition further diminishes active vasodilatation.<\/jats:p>","DOI":"10.1113\/jphysiol.2006.112508","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T00:40:25Z","timestamp":1160095225000},"page":"1043-1051","source":"Crossref","is-referenced-by-count":76,"title":["Neurokinin\u20101 receptor desensitization attenuates cutaneous active vasodilatation in humans"],"prefix":"10.1113","volume":"577","author":[{"given":"Brett J.","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher 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