{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:11:49Z","timestamp":1789992709967,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,8,24]],"date-time":"2006-08-24T00:00:00Z","timestamp":1156377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>Previous experiments have demonstrated that the vestibular system contributes to regulating sympathetic nervous system activity, particularly the discharges of vasoconstrictor fibres. In the present study, we examined the physiological significance of vestibulosympathetic responses by comparing blood flow and vascular resistance in the forelimb and hindlimb during head\u2010up tilt from the prone position before and after the removal of vestibular inputs through a bilateral vestibular neurectomy. Experiments were performed on conscious cats that were trained to remain sedentary on a tilt table during rotations up to 60 deg in amplitude. Blood flow through the femoral and brachial arteries was recorded during whole\u2010body tilt using perivascular probes; blood pressure was recorded using a telemetry system and vascular resistance was calculated from blood pressure and blood flow measurements. In vestibular\u2010intact animals, 60 deg head\u2010up tilt produced \u223c20% decrease in femoral blood flow and \u223c37% increase in femoral vascular resistance relative to baseline levels before tilt; similar effects were also observed for the brachial artery (\u223c25% decrease in blood flow and \u223c38% increase in resistance). Following the removal of vestibular inputs, brachial blood flow and vascular resistance during head\u2010up tilt were almost unchanged. In contrast, femoral vascular resistance increased only \u223c6% from baseline during 60 deg head\u2010up rotation delivered in the first week after elimination of vestibular signals and \u223c16% in the subsequent 3\u2010week period (as opposed to the \u223c37% increase in resistance that occurred before lesion). These data demonstrate that vestibular inputs associated with postural alterations elicit regionally specific increases in vascular resistance that direct blood flow away from the region of the body where blood pooling may occur. Thus, the data support the hypothesis that vestibular influences on the cardiovascular system serve to protect against the occurrence of orthostatic hypotension.<\/jats:p>","DOI":"10.1113\/jphysiol.2006.112904","type":"journal-article","created":{"date-parts":[[2006,6,30]],"date-time":"2006-06-30T14:27:06Z","timestamp":1151677626000},"page":"671-684","source":"Crossref","is-referenced-by-count":34,"title":["Vestibular inputs elicit patterned changes in limb blood flow in conscious cats"],"prefix":"10.1113","volume":"575","author":[{"given":"T. D.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. 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