{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:59:17Z","timestamp":1791421157298,"version":"4.3.3"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:00:00Z","timestamp":1154995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,8,15]]},"abstract":"<jats:p>\n                    The M\u2010current is a slowly activating, non\u2010inactivating potassium current that has been shown to be present in numerous cell types. In this study, KCNQ2, Q3 and Q5, the molecular correlates of M\u2010current in neurons, were identified in the visceral sensory neurons of the nodose ganglia from rats through immunocytochemical studies. All neurons showed expression of each of the three proteins. In voltage clamp studies, the cognition\u2010enhancing drug linopirdine (1\u201350 \u03bc\n                    <jats:sc>m<\/jats:sc>\n                    ) and its analogue, XE991 (10 \u03bc\n                    <jats:sc>m<\/jats:sc>\n                    ), quickly and irreversibly blocked a small, slowly activating current that had kinetic properties similar to KCNQ\/M\u2010currents. This current activated between \u221260 and \u221255 mV, had a voltage\u2010dependent activation time constant of 208 \u00b1 12 ms at \u221220 mV, a deactivation time constant of 165 \u00b1 24 ms at \u221250 mV and\n                    <jats:italic>V<\/jats:italic>\n                    <jats:sub>1\/2<\/jats:sub>\n                    of \u221224 \u00b1 2 mV, values which are consistent with previous reports for endogenous M\u2010currents. In current clamp studies, these drugs also led to a depolarization of the resting membrane potential at values as negative as \u221260 mV. Flupirtine (10\u201320 \u03bc\n                    <jats:sc>m<\/jats:sc>\n                    ), an M\u2010current activator, caused a 3\u201314 mV leftward shift in the current\u2013voltage relationship and also led to a hyperpolarization of resting membrane potential. These data indicate that the M\u2010current is present in nodose neurons, is activated at resting membrane potential and that it is physiologically important in regulating excitability by maintaining cells at negative voltages.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2006.113308","type":"journal-article","created":{"date-parts":[[2006,6,15]],"date-time":"2006-06-15T20:56:36Z","timestamp":1150404996000},"page":"175-189","source":"Crossref","is-referenced-by-count":131,"title":["KCNQ\/M\u2010currents contribute to the resting membrane potential in rat visceral sensory neurons"],"prefix":"10.1113","volume":"575","author":[{"given":"Cynthia L.","family":"Wladyka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L.","family":"Kunze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014357"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15019.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.107.4.473"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6107(00)00004-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/283673a0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000145629.94338.89"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(97)00155-X"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.4.1890"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4512-03.2004"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.125af.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-01-00084.2003"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200409041"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.018333"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.086835"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703086"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-12-05012.2003"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410340613"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/35036198"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)80082-E"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.5.2345"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1997.tb01637.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199909)46:3<305::AID-ANA5>3.0.CO;2-5"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002378200"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.58.2.253"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.59.1.483"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3143-03.2004"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702642"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0347i.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-18-07227.2003"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1375"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(01)00116-4"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704989"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)00866-1"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.6.3198"},{"key":"e_1_2_5_36_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0022-3565(24)37644-X","article-title":"Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage\u2010dependent and calcium\u2010activated potassium currents in hippocampal neurons","volume":"286","author":"Schnee ME","year":"1998","journal-title":"J Pharmacol Exp Therapeutics"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003245200"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-18-07742.1999"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-2-00349.x"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.028571"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-05-01710.2000"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-15-05535.2001"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01918-9"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)01296-4"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01586-6"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5395.1890"},{"key":"e_1_2_5_47_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1124\/mol.58.3.591","article-title":"Retigabine, a novel anti\u2010convulsant, enhances activation of KCNQ2\/Q3 potassium channels","volume":"53","author":"Wickenden AD","year":"2000","journal-title":"Mol Pharmacol"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703861"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053363045"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706342"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0765-04.2004"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2006.113308","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2006.113308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:31:49Z","timestamp":1736404309000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2006.113308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,8]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,8,15]]}},"alternative-id":["10.1113\/jphysiol.2006.113308"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2006.113308","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,8]]}}}