{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:24:13Z","timestamp":1791350653537,"version":"4.3.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T00:00:00Z","timestamp":1161907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>The morphological features of interstitial cells of Cajal (ICC) in the gastrointestinal (GI) tract are described based on observations of laboratory animals including mice, rats and guinea\u2010pigs, using immunohistochemical staining for Kit and electron microscopy. ICC show a specific distribution, arrangement and cell shape depending on their location within various regions and tissue layers of the GI tract. Hence they are classified into several subtypes. The stomach shows distinct regional variations in the distribution of subtypes of ICC from the cardia to pylorus, whereas the small intestine and colon both seem to retain nearly the same distribution pattern of subtypes of ICC throughout each organ. All subtypes of ICC share common ultrastructural features, such as the presence of numerous mitochondria, abundant intermediate filaments, and formation of gap junctions with the same type of cells and with smooth muscle cells. In addition, depending on their species and anatomical location, some subtypes of ICC show some features typical of smooth muscle cells including a basal lamina, caveolae, subsurface cisterns and dense bodies. ICC are somewhat heterogeneous morphologically. A question is raised on a special relationship between their ultrastructural features and dependency on Kit\/stem cell factor system. As the neuromediator function of ICC, reciprocal distribution of ICC and gap junctions in the muscle coat is demonstrated by the comparison of Kit immunoreactive cells and gap junction protein connexin 43 in both small intestine and colon.<\/jats:p>","DOI":"10.1113\/jphysiol.2006.116624","type":"journal-article","created":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T00:51:30Z","timestamp":1155862290000},"page":"653-658","source":"Crossref","is-referenced-by-count":157,"title":["Structure and organization of interstitial cells of Cajal in the gastrointestinal tract"],"prefix":"10.1113","volume":"576","author":[{"given":"Terumasa","family":"Komuro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20746"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902730105"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050902"},{"key":"e_1_2_6_5_1","first-page":"187","article-title":"Ultrastructural features and localization of the interstitial cells of Cajal in the smooth muscle coat of human esophagus","volume":"17","author":"Faussone\u2010Pellegrini MS","year":"1985","journal-title":"J Submicrosc Cytol Patol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(08)61662-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(98)00038-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(04)42006-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013672"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051119"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0237k.x"},{"key":"e_1_2_6_12_1","first-page":"303","article-title":"Morphological analysis of c\u2010kit expressing cells, with reference to interstitial cells of Cajal","volume":"31","author":"Horiguchi K","year":"1995","journal-title":"J Smooth Muscle Res"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90152-X"},{"key":"e_1_2_6_14_1","first-page":"393","article-title":"Interstitial cells of Cajal as targets for pharmacological intervention in gastrointestinal motor disorders","volume":"18","author":"Huizinga JD","year":"1997","journal-title":"TIPS"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00196314"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004410050859"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199801)211:1<60::AID-AJA6>3.0.CO;2-5"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00224117"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19991115)47:4<267::AID-JEMT5>3.0.CO;2-O"},{"key":"e_1_2_6_20_1","first-page":"109","volume-title":"Gastrointestinal Stromal Tumor (GIST): from pathology to molecular target therapy","author":"Komuro T","year":"2004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1679\/aohc.62.295"},{"key":"e_1_2_6_22_1","unstructured":"KunisawaY&KomuroT(2004).Interstitial cells of Cajal in the guinea\u2010pig gastric antrum. Distribution and Ultrastructure.Proceedings of the 8APEM 945\u2013946."},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1242\/dev.122.3.725","article-title":"Origin of the c\u2010kit\u2010positive interstitial cells in the avian bowel","volume":"122","author":"Lecoin L","year":"1996","journal-title":"Development"},{"key":"e_1_2_6_24_1","first-page":"G387","article-title":"Action potential generation in the small intestine of W mutant mice that lack interstitial cells of Cajal","volume":"271","author":"Malysz J","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-003-0835-9"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-003-0323-8"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092030112"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8690216"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004290050125"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-002-0279-0"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(97)00134-3"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-68417-3_1"},{"key":"e_1_2_6_33_1","first-page":"349","volume-title":"Handbook of Physiology. The Gastrointestinal System","author":"Thuneberg L","year":"1989"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(98)00174-X"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004419900170"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.269.6.C1577"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00475.2001"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70198-2"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0185(20010101)262:1<125::AID-AR1017>3.0.CO;2-I"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0287"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00318788"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2006.116624","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2006.116624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T18:06:58Z","timestamp":1697047618000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2006.116624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,27]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1113\/jphysiol.2006.116624"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2006.116624","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,27]]}}}