{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:58:16Z","timestamp":1791917896917,"version":"4.3.4"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T00:00:00Z","timestamp":1161907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>Pyeloureteric peristalsis has long been considered to be triggered by pacemaker atypical smooth muscle cells (SMC) located in the proximal regions of the renal pelvis. However, interstitial cells with many of the morphological features and c\u2010<jats:italic>Kit<\/jats:italic> immuno\u2010reactivity of interstitial cells of Cajal (ICC), the established pacemaker cells in the intestine, have been demonstrated to be present in small numbers within the ureteropelvic junction (UPJ) of many mammals. Freshly isolated ICC\u2010like cells (ICC\u2010LC) of the mouse UPJ also display autorhyhmicity. This review discusses the notion that ureteric peristalsis depends on the presence of both atypical SMC and ICC\u2010LC which form separate but interconnected networks that drive electrically quiescent typical SMC. In contrast to the intestine or prostate, all regenerative potential discharge in the mouse UPJ is abolished by the L\u2010type Ca<jats:sup>2+<\/jats:sup> channel blocker nifedipine revealing a fundamental pacemaker signal. Whether these pacemaker transients arise from atypical SMC or ICC\u2010LC or both has yet to be established. We speculate that the presence of spontaneously active ICC\u2010LC in the distal regions of the UPJ maintains rudimentary peristaltic waves and movement of urine towards the bladder after pyeloureteral obstruction or pyeloplasty and disconnection from the proximal pacemaker drive.<\/jats:p>","DOI":"10.1113\/jphysiol.2006.116855","type":"journal-article","created":{"date-parts":[[2006,9,1]],"date-time":"2006-09-01T00:18:35Z","timestamp":1157069915000},"page":"695-705","source":"Crossref","is-referenced-by-count":83,"title":["Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal\u2010like cells as pacemakers"],"prefix":"10.1113","volume":"576","author":[{"given":"Richard J.","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Tonta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata Z.","family":"Zoltkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Meeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Wendt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena C.","family":"Parkington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021300"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03834"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1152\/ajplegacy.1974.226.6.1413","article-title":"Renal pelvic pacemaker control of ureteral peristaltic rate","volume":"226","author":"Constantinou CE","year":"1974","journal-title":"Am J Physiol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000280229"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000141594.99139.3d"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703104"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091750203"},{"key":"e_1_2_10_9_1","first-page":"129","article-title":"The musculature of the human renal calices, pelvis and upper ureter","volume":"135","author":"Dixon JS","year":"1982","journal-title":"J Anat"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0683-2_8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00255872"},{"key":"e_1_2_10_12_1","first-page":"17","article-title":"Experimental hydronephrosis. 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