{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:58:30Z","timestamp":1792151910680,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T00:00:00Z","timestamp":1173830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2007,3,15]]},"abstract":"\n Acetazolamide (ACZ) is used to prevent acute mountain sickness at altitude. Because it could affect O\n 2<\/jats:sub>\n transport in several different and potentially conflicting ways, we examined its effects on pulmonary and muscle gas exchange and acid\u2013base status during cycle exercise at \u223c30, 50 and 90%\n \n in normoxia\n \n (\n F<\/jats:italic>\n \n = 0.2093)\n <\/jats:styled-content>\n and acute hypoxia\n \n (\n F<\/jats:italic>\n \n = 0.125)\n <\/jats:styled-content>\n . In a double\u2010blind, order\u2010balanced, crossover design, six healthy, trained men (normoxic\n \n = 59 ml kg\n \u22121<\/jats:sup>\n min\n \u22121<\/jats:sup>\n ) exercised at both\n \n F<\/jats:italic>\n \n <\/jats:styled-content>\n values after ACZ (3 doses of 250 mg, 8 h apart) and placebo. One week later this protocol was repeated using the other drug (placebo or ACZ). We measured cardiac output\n \n , leg blood flow (LBF), and muscle and pulmonary gas exchange, the latter using the multiple inert gas elimination technique. ACZ did not significantly affect\n \n ,\n \n , LBF or muscle gas exchange. As expected, ACZ led to lower arterial and venous blood [HCO\n 3<\/jats:sub>\n \u2212<\/jats:sup>\n ], pH and lactate levels (\n P<\/jats:italic>\n < 0.05), and increased ventilation (\n P<\/jats:italic>\n < 0.05). In both normoxia and hypoxia, ACZ resulted in higher arterial\n P<\/jats:italic>\n O2<\/jats:sub>\n and saturation and a lower alveolar\u2013arterial\n P<\/jats:italic>\n O2<\/jats:sub>\n difference (Aa\n D<\/jats:italic>\n O2<\/jats:sub>\n ) due to both less\n \n mismatch and less diffusion limitation (\n P<\/jats:italic>\n < 0.05). In summary, ACZ improved arterial oxygenation during exercise, due to both greater ventilation and more efficient pulmonary gas exchange. However, muscle gas exchange was unaffected.\n <\/jats:p>","DOI":"10.1113\/jphysiol.2006.120949","type":"journal-article","created":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T20:25:13Z","timestamp":1168547113000},"page":"909-921","source":"Crossref","is-referenced-by-count":64,"title":["Effect of acetazolamide on pulmonary and muscle gas exchange during normoxic and hypoxic exercise"],"prefix":"10.1113","volume":"579","author":[{"given":"Amy M.","family":"Jonk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene P.","family":"Van Den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. Mark","family":"Olfert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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