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In common with peripheral chronic inflammatory diseases such a rheumatoid arthritis and ulcerative colitis, evidence now exists for the involvement of inflammatory cytokines, for example tumour necrosis factor (TNF) and interleukins (IL), in neurological disorders. A common factor observed with the up\u2010regulation of these cytokines in peripheral inflammatory diseases, is the increased expression of the proteinase\u2010activated receptor (PAR) subtype PAR\u20102. Indeed, recent evidence suggests that targeting PAR\u20102 helps reduce joint swelling observed in animal models of arthritis. So could targeting this receptor prove to be useful in treating those CNS disorders where inflammatory processes are thought to play an intrinsic role? 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