{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:36:32Z","timestamp":1791142592190,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,7,21]],"date-time":"2007-07-21T00:00:00Z","timestamp":1184976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>The TRP superfamily of cation channels encompasses 28 mammalian members related to the product of the <jats:italic>Drosophila trp<\/jats:italic> (transient receptor potential) gene. TRP channels have a widespread distribution in many cell types and organs and gate in response to a broad variety of physical and chemical stimuli; as such, they can be considered as ubiquitous cellular sensors. Several recent studies reported modulation of different TRP channels by phosphoinositides, in particular by phosphatidylinositol 4,5\u2010bisphosphate (PIP<jats:sub>2<\/jats:sub>). In most cases, PIP<jats:sub>2<\/jats:sub> promotes TRP channel activation. Here we provide a brief overview of current insights and controversies about the mechanisms and structural determinants of PIP<jats:sub>2<\/jats:sub>\u2013TRP channel interactions, and zoom in on the regulation of the Ca<jats:sup>2+<\/jats:sup>\u2010 and voltage\u2010gated TRPM4 by phosphoinositides.<\/jats:p>","DOI":"10.1113\/jphysiol.2007.132522","type":"journal-article","created":{"date-parts":[[2007,3,30]],"date-time":"2007-03-30T00:35:00Z","timestamp":1175214900000},"page":"939-944","source":"Crossref","is-referenced-by-count":77,"title":["Modulation of TRPs by PIPs"],"prefix":"10.1113","volume":"582","author":[{"given":"Thomas","family":"Voets","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Nilius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,7,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35082088"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/16703"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/224285a0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0001m.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(92)90086-S"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/35093002"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00269-0"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.2001.111.re19"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00003.2004"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg080"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(03)00431-7"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.01.021"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00719-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200509314"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2334159100"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3632-04.2005"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1296-05.2005"},{"key":"e_1_2_5_19_1","article-title":"Dual regulation of TRPV1 by phosphatidylinositol 4,5\u2010bisphosphate","author":"Lukacs V","year":"2007","journal-title":"Biophysical Society Meeting Abstracts. 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