{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:01:50Z","timestamp":1785250910986,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T00:00:00Z","timestamp":1186444800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:p>The effect of voluntary hyperventilation\u2010induced hypocapnic alkalosis (RALK) on pulmonary O<jats:sub>2<\/jats:sub> uptake (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2369_mu2.gif\" xlink:title=\"inline image\"\/>) kinetics and muscle deoxygenation was examined in young male adults (<jats:italic>n<\/jats:italic>= 8) during moderate\u2010intensity exercise. Subjects performed five repetitions of a step\u2010transition in work rate from 20 W cycling to a work rate corresponding to 90% of the estimated lactate threshold during control (CON; <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2369_mu3.gif\" xlink:title=\"inline image\"\/>, \u223c40 mmHg) and during hyperventilation (RALK; <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2369_mu4.gif\" xlink:title=\"inline image\"\/>, \u223c20 mmHg). <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2369_mu5.gif\" xlink:title=\"inline image\"\/> was measured breath\u2010by\u2010breath and relative concentration changes in muscle deoxy\u2010 (\u0394HHb), oxy\u2010 (\u0394O<jats:sub>2<\/jats:sub>Hb) and total (\u0394Hb<jats:sub>tot<\/jats:sub>) haemoglobin were measured continuously using near\u2010infrared (NIR) spectroscopy (Hamamatsu, NIRO 300). The time constant for the fundamental, phase 2, <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2369_mu6.gif\" xlink:title=\"inline image\"\/> response (\u03c4<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2369_mu7.gif\" xlink:title=\"inline image\"\/>) was greater (<jats:italic>P<\/jats:italic> &lt; 0.05) in RALK (48 \u00b1 11 s) than CON (31 \u00b1 9 s), while \u03c4HHb was similar between conditions (RALK, 12 \u00b1 4 s; CON, 11 \u00b1 4 s). The \u0394Hb<jats:sub>tot<\/jats:sub> was lower (<jats:italic>P<\/jats:italic> &lt; 0.05) in RALK than CON, prior to (RALK, \u22123 \u00b1 5 \u03bcmol l<jats:sup>\u22121<\/jats:sup>; CON, \u22121 \u00b1 4 \u03bcmol l<jats:sup>\u22121<\/jats:sup>) and at the end (RALK, 1 \u00b1 6 \u03bcmol l<jats:sup>\u22121<\/jats:sup>; CON, 5 \u00b1 5 \u03bcmol l<jats:sup>\u22121<\/jats:sup>) of moderate\u2010intensity exercise. Although slower adaptation of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2369_mu8.gif\" xlink:title=\"inline image\"\/> during RALK may be related to an attenuated activation of PDH (and other enzymes) and provision of oxidizable substrate to the mitochondria (i.e. metabolic inertia), the present findings also suggest a role for a reduction in local muscle perfusion and O<jats:sub>2<\/jats:sub> delivery.<\/jats:p>","DOI":"10.1113\/jphysiol.2007.132837","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T00:54:57Z","timestamp":1182473697000},"page":"351-364","source":"Crossref","is-referenced-by-count":45,"title":["Hyperventilation\u2010induced hypocapnic alkalosis slows the adaptation of pulmonary O<sub>2<\/sub> uptake during the transition to moderate\u2010intensity exercise"],"prefix":"10.1113","volume":"583","author":[{"given":"Lisa M. 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