{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:43:55Z","timestamp":1792129435958,"version":"4.4.0"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,6,25]],"date-time":"2007-06-25T00:00:00Z","timestamp":1182729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>\n                    Inspiratory neurons of the preB\u00f6tzinger complex (preB\u00f6tC) form local excitatory networks and display 10\u201330 mV transient depolarizations, dubbed\n                    <jats:italic>inspiratory drive potentials<\/jats:italic>\n                    , with superimposed spiking. AMPA receptors are critical for rhythmogenesis under normal conditions\n                    <jats:italic>in vitro<\/jats:italic>\n                    but whether other postsynaptic mechanisms contribute to drive potential generation remains unknown. We examined synaptic and intrinsic membrane properties that generate inspiratory drive potentials in preB\u00f6tC neurons using neonatal mouse medullary slice preparations that generate respiratory rhythm. We found that NMDA receptors, group I metabotropic glutamate receptors (mGluRs), but not group II mGluRs, contributed to inspiratory drive potentials. Subtype 1 of the group I mGluR family (mGluR1) probably regulates a K\n                    <jats:sup>+<\/jats:sup>\n                    channel, whereas mGluR5 operates via an inositol 1,4,5\u2010trisphosphate (IP\n                    <jats:sub>3<\/jats:sub>\n                    ) receptor\u2010dependent mechanism to augment drive potential generation. We tested for and verified the presence of a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010activated non\u2010specific cation current (\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sub>CAN<\/jats:sub>\n                    ) in preB\u00f6tC neurons. We also found that high concentrations of intracellular BAPTA, a high\u2010affinity Ca\n                    <jats:sup>2+<\/jats:sup>\n                    chelator, and the\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sub>CAN<\/jats:sub>\n                    antagonist flufenamic acid (FFA) decreased the magnitude of drive potentials. We conclude that\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sub>CAN<\/jats:sub>\n                    underlies robust inspiratory drive potentials in preB\u00f6tC neurons, and is only fully evoked by ionotropic and metabotropic glutamatergic synaptic inputs, i.e. by network activity.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2007.133660","type":"journal-article","created":{"date-parts":[[2007,4,19]],"date-time":"2007-04-19T20:14:14Z","timestamp":1177013654000},"page":"113-125","source":"Crossref","is-referenced-by-count":199,"title":["Inspiratory bursts in the preB\u00f6tzinger complex depend on a calcium\u2010activated non\u2010specific cation current linked to glutamate receptors in neonatal mice"],"prefix":"10.1113","volume":"582","author":[{"given":"Ryland W.","family":"Pace","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin D.","family":"Mackay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack L.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Del Negro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1784"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01056.2006"},{"key":"e_1_2_5_4_1","unstructured":"BellinghamM(2006).Riluzole decreases synaptic excitation and repetitive firing in rat hypoglossal motor neurons.Society for Neuroscience Annual Meeting: Neuroscience 2006 Atlanta GA USA. 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