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Abnormal connections in visual cortex are known to underlie this loss, but the extent to which these abnormalities are regionally or retinotopically specific has not been fully determined. This functional magnetic resonance imaging (fMRI) study compared the retinotopic maps in visual cortex produced by each individual eye in 19 adults (7 esotropic strabismics, 6 anisometropes and 6 controls). In our standard viewing condition, the non\u2010tested eye viewed a dichoptic homogeneous mid\u2010level grey stimulus, thereby permitting some degree of binocular interaction. Regions\u2010of\u2010interest analysis was performed for extrafoveal V1, extrafoveal V2 and the foveal representation at the occipital pole. In general, the blood oxygenation level\u2010dependent (BOLD) signal was reduced for the amblyopic eye. At the occipital pole, population receptive fields were shifted to represent more parafoveal locations for the amblyopic eye, compared with the fellow eye, in some subjects. Interestingly, occluding the fellow eye caused an expanded foveal representation for the amblyopic eye in one early\u2013onset strabismic subject with binocular suppression, indicating real\u2010time cortical remapping. In addition, a few subjects actually showed increased activity in parietal and temporal cortex when viewing with the amblyopic eye. We conclude that, even in a heterogeneous population, abnormal early visual experience commonly leads to regionally specific cortical adaptations.<\/jats:p>","DOI":"10.1113\/jphysiol.2007.136242","type":"journal-article","created":{"date-parts":[[2007,7,13]],"date-time":"2007-07-13T01:07:58Z","timestamp":1184288878000},"page":"159-173","source":"Crossref","is-referenced-by-count":35,"title":["Retinotopic maps and foveal suppression in the visual cortex of amblyopic adults"],"prefix":"10.1113","volume":"583","author":[{"given":"Ian P.","family":"Conner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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