{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:11:28Z","timestamp":1792620688331,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T00:00:00Z","timestamp":1190937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"\n This study examined cerebrovascular reactivity and ventilation during step changes in CO\n 2<\/jats:sub>\n in humans. We hypothesized that: (1) end\u2010tidal\n \n P<\/jats:italic>\n \n (\n P<\/jats:italic>\n \n )\n <\/jats:styled-content>\n would overestimate arterial\n \n P<\/jats:italic>\n \n (\n P<\/jats:italic>\n \n )\n <\/jats:styled-content>\n during step variations in\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n and thus underestimate cerebrovascular CO\n 2<\/jats:sub>\n reactivity; and (2) since\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n from the internal jugular vein\n \n (\n P<\/jats:italic>\n \n )\n <\/jats:styled-content>\n better represents brain tissue\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n , cerebrovascular CO\n 2<\/jats:sub>\n reactivity would be higher when expressed against\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n than with\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n , and would be related to the degree of ventilatory change during hypercapnia. Incremental hypercapnia was achieved through 4 min administrations of 4% and 8% CO\n 2<\/jats:sub>\n . Incremental hypocapnia involved two 4 min steps of hyperventilation to change\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n , in an equal and opposite direction, to that incurred during hypercapnia. Arterial and internal jugular venous blood was sampled simultaneously at baseline and during each CO\n 2<\/jats:sub>\n step. Cerebrovascular reactivity to CO\n 2<\/jats:sub>\n was expressed as the percentage change in blood flow velocity in the middle cerebral artery (MCAv) per mmHg change in\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n and\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n . During hypercapnia, but not hypocapnia,\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n overestimated\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n by +2.4 \u00b1 3.4 mmHg and underestimated MCAv\u2010CO\n 2<\/jats:sub>\n reactivity (\n P<\/jats:italic>\n < 0.05). The hypercapnic and hypocapnic MCAv\u2010CO\n 2<\/jats:sub>\n reactivity was higher (\u223c97% and \u223c24%, respectively) when expressed with\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n than\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n (\n P<\/jats:italic>\n < 0.05). The hypercapnic MCAv\u2013\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n reactivity was inversely related to the increase in ventilatory change (\n R<\/jats:italic>\n 2<\/jats:sup>\n = 0.43;\n P<\/jats:italic>\n < 0.05), indicating that a reduced reactivity results in less central CO\n 2<\/jats:sub>\n washout and greater ventilatory stimulus. Differences in the\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n ,\n \n P<\/jats:italic>\n \n <\/jats:styled-content>\n and\n \n P<\/jats:italic>\n \n \u2013MCAv\n <\/jats:styled-content>\n relationships have implications for the true representation and physiological interpretation of cerebrovascular CO\n 2<\/jats:sub>\n reactivity.\n <\/jats:p>","DOI":"10.1113\/jphysiol.2007.137075","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T20:35:02Z","timestamp":1186691702000},"page":"347-357","source":"Crossref","is-referenced-by-count":136,"title":["Human cerebrovascular and ventilatory CO\n 2<\/sub>\n reactivity to end\u2010tidal, arterial and internal jugular vein\n P<\/i>\n CO2<\/sub>"],"prefix":"10.1113","volume":"584","author":[{"given":"Karen","family":"Peebles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Celi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"McGrattan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carissa","family":"Murrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip N.","family":"Ainslie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.57.6.0769"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580791"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00911.2006"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199826040-00002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1962.tb02329.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-005-0057-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01437.2006"},{"key":"e_1_2_5_10_1","first-page":"75","article-title":"Comparison of rebreathing estimates with direct measurements of mixed venous PCO2 and PO2 in man","volume":"202","author":"Denison D","year":"1969","journal-title":"J Physiol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(69)90016-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1152\/jappl.1993.75.3.1306","article-title":"Effect of inspired CO2 on ventilation and perfusion heterogeneity in hyperventilated dogs","volume":"75","author":"Domino K","year":"1993","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-004-1296-z"},{"key":"e_1_2_5_14_1","volume-title":"Acid\u2013Base Blance in Cerebral Fluids","author":"Fencl V","year":"1986"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199305000-00006"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.056895"},{"key":"e_1_2_5_17_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1152\/jappl.1979.47.1.67","article-title":"Gas\u2010to\u2010blood PCO2 differences during severe hypercapnia","volume":"47","author":"Gurtner G","year":"1979","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(73)90060-1"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01186.2002"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-006-0136-6"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.38.3.382"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.47.5.954"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021308"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101994"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(71)90099-5"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1984.54"},{"key":"e_1_2_5_27_1","first-page":"236","article-title":"The effects of acute bronchoconstriction on respiratory activity in patients with chronic obstructive pulmonary disease","volume":"131","author":"Oliven A","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019913"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.68.4.1727"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.7.1672"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00471.2004"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.20.2.272"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105406"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00926.2005"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.76.349"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.38.445"},{"key":"e_1_2_5_37_1","first-page":"1929","article-title":"Changes in blood flow velocity and diameter of the middle cerebral artery during hyperventilation: assessment with MR and transcranial Doppler sonography","volume":"18","author":"Valdueza JM","year":"1997","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-004-1274-3"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104359"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.10.1963"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20193"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600465"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200406-807OC"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.110627"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2007.137075","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2007.137075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:13:42Z","timestamp":1696972422000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2007.137075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,28]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1113\/jphysiol.2007.137075"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2007.137075","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1090405.543663","asserted-by":"object"}]},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,28]]}}}