{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T02:33:13Z","timestamp":1763346793282},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,8,30]],"date-time":"2007-08-30T00:00:00Z","timestamp":1188432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>With one billion people overweight worldwide, the need to identify risk factors and treatments for obesity is urgent. The present study determined whether rats genetically prone to diet\u2010induced obesity (DIO) show preexisting differences in meal microstructure and are sensitive to central anorectic effects of corticotropin\u2010releasing factor type 2 (CRF<jats:sub>2<\/jats:sub>) receptor stimulation. Male, selectively bred DIO rats and their diet resistant (DR) counterparts (<jats:italic>n<\/jats:italic>= 9\/genotype) were weaned onto low\u2010fat chow and compared as young adults for spontaneous or intracerebroventricular urocortin 2 administration\u2010induced (0, 0.3, 1, 3 \u03bcg) differences in ingestion. DIO rats were hyperphagic selectively at the dark cycle onset, showing shorter latencies to initiate feeding, faster returns to eating following meal completion, and a lower satiety ratio than DR rats. At other times, DIO rats had briefer postmeal intervals, but ate smaller and briefer meals, resulting in normal intake. DIO rats also ate faster than DR rats. Urocortin 2 was less potent in DIO rats, ineffective at the 0.3 \u03bcg dose, but produced CRF<jats:sub>2<\/jats:sub> antagonist\u2010reversible anorexia at higher doses. Though heavier, chow\u2010maintained DIO rats were proportionately as or more lean than DR rats. Thus, DIO rats showed signs of a preexisting, heritable deficit in the maintenance of postmeal satiety and a reduced sensitivity to anorectic CRF<jats:sub>2<\/jats:sub> agonist stimulation. The meal patterns of DIO rats temporally resemble human \u2018snacking\u2019 behaviour, which predicts adult obesity. Because central CRF<jats:sub>2<\/jats:sub> stimulation retains full anorectic efficacy at higher doses in the DIO model, manipulating this neuropeptidergic system might yield new therapeutic approaches for diet\u2010induced obesity.<\/jats:p>","DOI":"10.1113\/jphysiol.2007.138867","type":"journal-article","created":{"date-parts":[[2007,7,13]],"date-time":"2007-07-13T01:07:58Z","timestamp":1184288878000},"page":"487-504","source":"Crossref","is-referenced-by-count":42,"title":["Feeding microstructure in diet\u2010induced obesity susceptible <i>versus<\/i> resistant rats: central effects of urocortin 2"],"prefix":"10.1113","volume":"583","author":[{"given":"Pietro","family":"Cottone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Sabino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim 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