{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:58:04Z","timestamp":1791025084652,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,1,2]],"date-time":"2008-01-02T00:00:00Z","timestamp":1199232000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:p>The purpose of the present study was to identify the effects of an acute injection of a dual dopamine (DA)\/noradrenaline (NA) reuptake inhibitor (bupropion) on exercise performance, thermoregulation and neurotransmitters in the preoptic area and anterior hypothalamus (PO\/AH) of the rat during exercise in the heat. Body core temperature (<jats:italic>T<\/jats:italic><jats:sub>core<\/jats:sub>), brain temperature (<jats:italic>T<\/jats:italic><jats:sub>brain<\/jats:sub>) and tail skin temperature (<jats:italic>T<\/jats:italic><jats:sub>tail<\/jats:sub>) were measured. A microdialysis probe was inserted in the PO\/AH, and samples for measurement of extracellular DA, NA and serotonin (5\u2010HT) levels were collected. Rats received either bupropion (17 mg kg<jats:sup>\u22121<\/jats:sup>; hot\u2010BUP) or saline (1 ml kg<jats:sup>\u22121<\/jats:sup>; hot) 20 min before the start of exercise and ran at a speed of 26 m min<jats:sup>\u22121<\/jats:sup> until exhaustion in a warm environment (30\u00b0C). Rats also ran until exhaustion in a cool environment (18\u00b0C; cool). Running time to exhaustion was significantly influenced by the ambient temperature, and it was increased by bupropion in the heat (cool, 143.6 \u00b1 21 min; hot, 65.8 \u00b1 13 min; hot\u2010BUP, 86.3 \u00b1 7.2 min). <jats:italic>T<\/jats:italic><jats:sub>core<\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub>brain<\/jats:sub> at exhaustion were significantly higher in the bupropion group compared to the cool and hot groups, respectively. <jats:italic>T<\/jats:italic><jats:sub>tail<\/jats:sub> measured at exhaustion was not significantly different between the two hot conditions. Extracellular concentrations of DA and NA in the PO\/AH increased during exercise, and was significantly higher in the bupropion than in cool and hot groups (<jats:italic>P<\/jats:italic> &lt; 0.05). No differences were observed between groups for 5\u2010HT levels. These results suggest that DA and NA in the PO\/AH might be responsible for the increase in exercise performance and <jats:italic>T<\/jats:italic><jats:sub>core<\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub>brain<\/jats:sub> in the bupropion group in hyperthermia. Moreover, these results support previous findings in humans that acute bupropion ingestion increases <jats:italic>T<\/jats:italic><jats:sub>core<\/jats:sub> during exercise in the heat, indicating the possibility of an important role for DA and NA in thermoregulation.<\/jats:p>","DOI":"10.1113\/jphysiol.2007.142190","type":"journal-article","created":{"date-parts":[[2007,10,19]],"date-time":"2007-10-19T00:34:52Z","timestamp":1192754092000},"page":"141-149","source":"Crossref","is-referenced-by-count":88,"title":["Influence of brain catecholamines on the development of fatigue in exercising rats in the heat"],"prefix":"10.1113","volume":"586","author":[{"given":"Hiroshi","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Francesca","family":"Piacentini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Sarre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette","family":"Michotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Ishiwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Meeusen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.48.030186.003231"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-0800-z"},{"key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1152\/jappl.1991.71.4.1593","article-title":"Intracranial self\u2010stimulation motivates treadmill running in rats.","volume":"71","author":"Burgess ML","year":"1991","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1989.tb08715.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.5.1731"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(86)90025-4"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02355.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1980.sp013147"},{"key":"e_1_2_5_10_1","first-page":"178","volume-title":"Nutrition in Sport","author":"Davis JM","year":"2000"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199701000-00008"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.3.877"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199709000-00018"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.3.1032"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-971973"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00435.2005"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01276-3"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(82)80179-6"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-007-0450-7"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02066.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199520030-00004"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-15648"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-972683"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(68)90178-9"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019482"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004240100515"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.3.1040"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(89)90031-6"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.t01-1-00279.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2004.03.005"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.3.902"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5400.401"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01058.2002"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2002.10142578"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2002.000760"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200207000-00021"},{"key":"e_1_2_5_37_1","first-page":"R378","article-title":"Microdialysis of noradrenaline into preoptic area of guinea pigs: characteristics of hypothermic effect.","volume":"261","author":"Quan N","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_5_38_1","doi-asserted-by":"crossref","first-page":"R407","DOI":"10.1152\/ajpregu.1992.262.3.R407","article-title":"Preoptic noradrenaline\u2010induced hypothermia is mediated by alpha 2\u2010adrenoceptors.","volume":"262","author":"Quan N","year":"1992","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200636080-00004"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90403-5"},{"key":"e_1_2_5_41_1","first-page":"185","article-title":"Microbore liquid chromatography analysis of monoamine transmitters.","volume":"72","author":"Sarre S","year":"1997","journal-title":"Methods Mol Biol"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1369.020"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/0265673021000054621"},{"key":"e_1_2_5_44_1","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1152\/jappl.1984.57.6.1872","article-title":"Temperature regulation during treadmill exercise in the rat.","volume":"57","author":"Shellock FG","year":"1984","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-23-07416.1996"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01977.x"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.2.799"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.079202"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00319.2006"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2007.142190","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2007.142190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:16:12Z","timestamp":1696990572000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2007.142190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["10.1113\/jphysiol.2007.142190"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2007.142190","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}