{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:49:06Z","timestamp":1791341346771,"version":"4.3.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,14]],"date-time":"2007-11-14T00:00:00Z","timestamp":1194998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2007,11,15]]},"abstract":"<jats:p>Reactive hyperaemia is the increase in blood flow following arterial occlusion. The exact mechanisms mediating this response in skin are not fully understood. The purpose of this study was to investigate the individual and combined contributions of (1) sensory nerves and large\u2010conductance calcium activated potassium (BK<jats:sub>Ca<\/jats:sub>) channels, and (2) nitric oxide (NO) and prostanoids to cutaneous reactive hyperaemia. Laser\u2010Doppler flowmetry was used to measure skin blood flow in a total of 18 subjects. Peak blood flow (BF) was defined as the highest blood flow value after release of the pressure cuff. Total hyperaemic response was calculated by taking the area under the curve (AUC) of the hyperaemic response minus baseline. Infusates were perfused through forearm skin using microdialysis in four sites. In the sensory nerve\/BK<jats:sub>Ca<\/jats:sub>protocol: (1) EMLA<jats:sup>\u00ae<\/jats:sup>cream (EMLA, applied topically to skin surface), (2) tetraethylammonium (TEA), (3) EMLA<jats:sup>\u00ae<\/jats:sup>+ TEA (Combo), and (4) Ringer solution (Control). In the prostanoid\/NO protocol: (1) ketorolac (Keto), (2)<jats:italic>N<\/jats:italic><jats:sup>G<\/jats:sup>\u2010nitro\u2010<jats:sc>l<\/jats:sc>\u2010arginine methyl ester (<jats:sc>l<\/jats:sc>\u2010NAME), (3) Keto +<jats:sc>l<\/jats:sc>\u2010NAME (Combo), and (4) Ringer solution (Control). CVC was calculated as flux\/mean arterial pressure and normalized to maximal flow. Hyperaemic responses in Control (1389 \u00b1 794%CVC<jats:sub>max<\/jats:sub>s) were significantly greater compared to TEA, EMLA and Combo sites (TEA, 630 \u00b1 512,<jats:italic>P<\/jats:italic>= 0.003; EMLA, 421 \u00b1 216,<jats:italic>P<\/jats:italic>&lt; 0.001; Combo, 201 \u00b1 200,<jats:italic>P<\/jats:italic>&lt; 0.001%CVC<jats:sub>max<\/jats:sub>s). Furthermore, AUC in Combo (Keto +<jats:sc>l<\/jats:sc>\u2010NAME) site was significantly greater than Control (4109 \u00b1 2777<jats:italic>versus<\/jats:italic>1295 \u00b1 368%CVC<jats:sub>max<\/jats:sub>s). These data suggest (1) sensory nerves and BK<jats:sub>Ca<\/jats:sub>channels play major roles in the EDHF component of reactive hyperaemia and appear to work partly independent of each other, and (2) the COX pathway does not appear to have a vasodilatory role in cutaneous reactive hyperaemia.<\/jats:p>","DOI":"10.1113\/jphysiol.2007.143867","type":"journal-article","created":{"date-parts":[[2007,9,28]],"date-time":"2007-09-28T00:35:15Z","timestamp":1190939715000},"page":"295-303","source":"Crossref","is-referenced-by-count":172,"title":["Human cutaneous reactive hyperaemia: role of BK<sub>Ca<\/sub>channels and sensory nerves"],"prefix":"10.1113","volume":"585","author":[{"given":"Santiago","family":"Lorenzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Minson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb17172.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.12.3341"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00505-9"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1959.sp006313"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.3.415"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701629"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.79.4.631"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10739680490449268"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000217611.81085.c5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000105763.51286.7F"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.080952"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000155332.17783.26"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000097548.92665.16"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.3.824"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011358"},{"key":"e_1_2_5_17_1","first-page":"238","article-title":"Endothelium\u2010derived hyperpolarizing factor","volume":"27","author":"Komori K","year":"1990","journal-title":"Blood Vessels"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.73.1.147"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00710.2005"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01217.2006"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2281.1999.00173.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"C799","DOI":"10.1152\/ajpcell.1995.268.4.C799","article-title":"Physiological roles and properties of potassium channels in arterial smooth\u2010muscle","volume":"37","author":"Nelson MT","year":"1995","journal-title":"Am J Physiol Cell Physiol"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1979.tb06411.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.278.1.H233"},{"key":"e_1_2_5_25_1","first-page":"17","article-title":"The role of intravascular pressure in the causation of reactive hyperemia in the human forearm","volume":"15","author":"Patterson G","year":"1956","journal-title":"Clin Sci"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701032"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.32.6.1071"},{"key":"e_1_2_5_28_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1152\/jappl.1991.70.1.363","article-title":"Preservation of oscillations in postocclusive reactive hyperemia","volume":"70","author":"Schmedtje JF","year":"1991","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00254.2003"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.071779"},{"key":"e_1_2_5_31_1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0022-3565(24)37433-6","article-title":"Characterization of endothelium\u2010dependent relaxation independent of NO and prostaglandins in guinea pig coronary artery","volume":"285","author":"Yamanaka A","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00639.2003"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2007.143867","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2007.143867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T07:29:03Z","timestamp":1737444543000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2007.143867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,14]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,11,15]]}},"alternative-id":["10.1113\/jphysiol.2007.143867"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2007.143867","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,14]]}}}