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Here, we aimed to address whether the transient outward potassium current (<jats:italic>I<\/jats:italic><jats:sub>A<\/jats:sub>) in identified rostral ventrolateral medulla (RVLM)\u2010projecting PVN neurones is altered in hypertensive rats, and whether such changes affected single and repetitive action potential properties and associated changes in intracellular Ca<jats:sup>2+<\/jats:sup> levels. Patch\u2010clamp recordings obtained from PVN\u2010RVLM neurons showed a reduction in <jats:italic>I<\/jats:italic><jats:sub>A<\/jats:sub> current magnitude and single channel conductance, and an enhanced steady\u2010state current inactivation in hypertensive rats. Morphometric reconstructions of intracellularly labelled PVN\u2010RVLM neurons showed a diminished dendritic surface area in hypertensive rats. Consistent with a diminished <jats:italic>I<\/jats:italic><jats:sub>A<\/jats:sub> availability, action potentials in PVN\u2010RVLM neurons in hypertensive rats were broader, decayed more slowly, and were less sensitive to the K<jats:sup>+<\/jats:sup> channel blocker 4\u2010aminopyridine. Simultaneous patch clamp recordings and confocal Ca<jats:sup>2+<\/jats:sup> imaging demonstrated enhanced action potential\u2010evoked intracellular Ca<jats:sup>2+<\/jats:sup> transients in hypertensive rats. Finally, spike broadening during repetitive firing discharge was enhanced in PVN\u2010RVLM neurons from hypertensive rats. Altogether, our results indicate that diminished <jats:italic>I<\/jats:italic><jats:sub>A<\/jats:sub> availability constitutes a contributing mechanism underlying aberrant central neuronal function in renovascular hypertension.<\/jats:p>","DOI":"10.1113\/jphysiol.2007.147413","type":"journal-article","created":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T01:25:59Z","timestamp":1201829159000},"page":"1605-1622","source":"Crossref","is-referenced-by-count":31,"title":["Diminished A\u2010type potassium current and altered firing properties in presympathetic PVN neurones in renovascular hypertensive rats"],"prefix":"10.1113","volume":"586","author":[{"given":"Patrick M.","family":"Sonner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica A.","family":"Filosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier 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