{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:15:34Z","timestamp":1791062134496,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2008,5,15]]},"abstract":"<jats:p>Perfusion to exercising skeletal muscle is regulated to match O<jats:sub>2<\/jats:sub>delivery to the O<jats:sub>2<\/jats:sub>demand, but this regulation might be compromised during or approaching maximal whole\u2010body exercise as muscle blood flow for a given work rate is blunted. Whether muscle perfusion is restricted when there is an extreme metabolic stimulus to vasodilate during supramaximal exercise remains unknown. To examine the regulatory limits of systemic and muscle perfusion in exercising humans, we measured systemic and leg haemodynamics, O<jats:sub>2<\/jats:sub>transport, and<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2873_mu2.gif\" xlink:title=\"inline image\"\/>, and estimated non\u2010locomotor tissue perfusion during constant load supramaximal cycling (498 \u00b1 16 W; 110% of peak power; mean \u00b1<jats:sc>s.e.m.<\/jats:sc>) in addition to both incremental cycling and knee\u2010extensor exercise to exhaustion in 13 trained males. During supramaximal cycling, cardiac output (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2873_mu3.gif\" xlink:title=\"inline image\"\/>), leg blood flow (LBF), and systemic and leg O<jats:sub>2<\/jats:sub>delivery and<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2873_mu4.gif\" xlink:title=\"inline image\"\/>reached peak values after 60\u201390 s and thereafter levelled off at values similar to or \u223c6% (<jats:italic>P<\/jats:italic>&lt; 0.05) below maximal cycling, while upper body blood flow remained unchanged (\u223c5.5 l min<jats:sup>\u22121<\/jats:sup>). In contrast,<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2873_mu5.gif\" xlink:title=\"inline image\"\/>and LBF increased linearly until exhaustion during one\u2010legged knee\u2010extensor exercise accompanying increases in non\u2010locomotor tissue blood flow to \u223c12 l min<jats:sup>\u22121<\/jats:sup>. At exhaustion during cycling compared to knee\u2010extensor exercise,<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2873_mu6.gif\" xlink:title=\"inline image\"\/>, LBF, leg vascular conductance, leg O<jats:sub>2<\/jats:sub>delivery and leg<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2873_mu7.gif\" xlink:title=\"inline image\"\/>for a given power were reduced by 32\u201347% (<jats:italic>P<\/jats:italic>&lt; 0.05). In conclusion, locomotor skeletal muscle perfusion is restricted during maximal and supramaximal whole\u2013body exercise in association with a plateau in<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_2873_mu8.gif\" xlink:title=\"inline image\"\/>and limb vascular conductance. These observations suggest that limits of cardiac function and muscle vasoconstriction underlie the inability of the circulatory system to meet the increasing metabolic demand of skeletal muscles and other tissues during whole\u2010body exercise.<\/jats:p>","DOI":"10.1113\/jphysiol.2007.149401","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T00:26:54Z","timestamp":1206664014000},"page":"2621-2635","source":"Crossref","is-referenced-by-count":145,"title":["Restrictions in systemic and locomotor skeletal muscle perfusion, oxygen supply and<i>V<\/i><sub>O2<\/sub>during high\u2010intensity whole\u2010body exercise in humans"],"prefix":"10.1113","volume":"586","author":[{"given":"Stefan P.","family":"Mortensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Damsgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen 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