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In 22 spontaneously breathing pentobarbital\u2010anaesthetized rats, inspiration was occluded for 30 s every 2 min for 3 h. After \u223c1.5 h, mean arterial pressure started to fall; heart rate between occlusions was stable throughout, consistent with only transient increases in sympathetic activity during each occlusion. Three hours of occlusions resulted in ventricular diastolic dysfunction (reduced peak rate of change of ventricular pressure and slower relaxation). Post\u2010occlusions, the left ventricular contractile response to dobutamine was blunted. After 1 h of recovery, left ventricular pressure generation had returned to values no different from those in sham animals in 5 of 9 of the animals. Cardiac myofibrils from rats subjected to occlusions had depressed calcium\u2010activated myosin ATPase activity, indicating myofilament contractile dysfunction that was not due to breakdown of contractile proteins. Haematoxylin and eosin\u2010stained cross\u2010sections revealed multifocal areas of necrosis within the septum and both ventricles. Repeated inspiratory occlusions, analogous to moderately severe obstructive sleep apnoea, acutely cause global cardiac dysfunction with multifocal myocardial infarcts.<\/jats:p>","DOI":"10.1113\/jphysiol.2007.150086","type":"journal-article","created":{"date-parts":[[2008,3,7]],"date-time":"2008-03-07T01:34:54Z","timestamp":1204853694000},"page":"2345-2355","source":"Crossref","is-referenced-by-count":21,"title":["Repeated inspiratory occlusions acutely impair myocardial function in rats"],"prefix":"10.1113","volume":"586","author":[{"given":"Jeremy A.","family":"Simpson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith 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