{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:01:01Z","timestamp":1774303261309,"version":"3.50.1"},"reference-count":128,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":44,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2008,5,15]]},"abstract":"<jats:p>Voltage\u2010gated sodium channels (Na<jats:sub>v<\/jats:sub> channels) in retinal neurons are known to contribute to the mammalian flash electroretinogram (ERG) via activity of third\u2010order retinal neurons, i.e. amacrine and ganglion cells. This study investigated the effects of tetrodotoxin (TTX) blockade of Na<jats:sub>v<\/jats:sub> channels on the b\u2010wave, an ERG wave that originates mainly from activity of second\u2010order retinal neurons. ERGs were recorded from anaesthetized Brown Norway rats in response to brief full\u2010field flashes presented over a range of stimulus energies, under dark\u2010adapted conditions and in the presence of steady mesopic and photopic backgrounds. Recordings were made before and after intravitreal injection of TTX (\u223c3 \u03bc<jats:sc>m<\/jats:sc>) alone, 3\u20136 weeks after optic nerve transection (ONTx) to induce ganglion cell degeneration, or in combination with an ionotropic glutamate receptor antagonist 6\u2010cyano\u20107\u2010nitroquinoxaline\u20102,3\u2010dione (CNQX, 200 \u03bc<jats:sc>m<\/jats:sc>) to block light\u2010evoked activity of inner retinal, horizontal and OFF bipolar cells, or with the glutamate agonist <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate (NMDA, 100\u2013200 \u03bc<jats:sc>m<\/jats:sc>) to reduce light\u2010evoked inner retinal activity. TTX reduced ERG amplitudes measured at fixed times corresponding to b\u2010wave time to peak. Effects of TTX were seen under all background conditions, but were greatest for mesopic backgrounds. In dark\u2010adapted retina, b\u2010wave amplitudes were reduced only when very low stimulus energies affecting the inner retina, or very high stimulus energies were used. Loss of ganglion cells following ONTx did not affect b\u2010wave amplitudes, and injection of TTX in eyes with ONTx reduced b\u2010wave amplitudes by the same amount for each background condition as occurred when ganglion cells were intact, thereby eliminating a ganglion cell role in the TTX effects. Isolation of cone\u2010driven responses by presenting test flashes after cessation of a rod\u2010saturating conditioning flash indicated that the TTX effects were primarily on cone circuits contributing to the mixed rod\u2013cone ERG. NMDA significantly reduced only the additional effects of TTX on the mixed rod\u2013cone ERG observed under mesopic conditions, implicating inner retinal involvement in those effects. After pharmacological blockade with CNQX, TTX still reduced b\u2010wave amplitudes in cone\u2010isolated ERGs indicating Na<jats:sub>v<\/jats:sub> channels in ON cone bipolar cells themselves augment b\u2010wave amplitude and sensitivity. This augmentation was largest under dark\u2010adapted conditions, and decreased with increasing background illumination, indicating effects of background illumination on Na<jats:sub>v<\/jats:sub> channel function. These findings indicate that activation of Na<jats:sub>v<\/jats:sub> channels in ON cone bipolar cells affects the b\u2010wave of the rat ERG and must be considered when analysing results of ERG studies of retinal function.<\/jats:p>","DOI":"10.1113\/jphysiol.2008.150755","type":"journal-article","created":{"date-parts":[[2008,4,4]],"date-time":"2008-04-04T00:45:19Z","timestamp":1207269919000},"page":"2551-2580","source":"Crossref","is-referenced-by-count":52,"title":["Contribution of voltage\u2010gated sodium channels to the b\u2010wave of the mammalian flash electroretinogram"],"prefix":"10.1113","volume":"586","author":[{"given":"Deb Kumar","family":"Mojumder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Sherry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura J.","family":"Frishman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"S15","article-title":"Pharmacological removal of positive and negative STRs is required to isolate bipolar cell responses in the macaque scotopic electroretinogram","volume":"40","author":"Ahmed J","year":"1999","journal-title":"Invest Opthalmol Vis Sci"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523803202029"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523801181149"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00879.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(79)90106-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.120.8.1045"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(85)80105-1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(98)00139-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-07-02874.1993"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.052738"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523806232024"},{"key":"e_1_2_6_13_1","first-page":"2054","article-title":"Preservation of inner retinal responses in the aged Royal College of Surgeons rat. Evidence against glutamate excitotoxicity in photoreceptor degeneration","volume":"36","author":"Bush RA","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_14_1","first-page":"635","article-title":"A proximal retinal component in the primate photopic ERG a\u2010wave","volume":"35","author":"Bush RA","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012764422711"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4160(90)90014-L"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018525222826"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523801185135"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800001668"},{"key":"e_1_2_6_20_1","first-page":"988","article-title":"Improved electrode for electroretinography","volume":"18","author":"Dawson WW","year":"1979","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)01046-2"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1984.tb01355.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3328-04.2005"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00169-4"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901950210"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(99)00203-5"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(02)00032-9"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.22.1.74.6974"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.103648"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90401-1"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1523\/JNEUROSCI.16-14-04479.1996","article-title":"Immunocytochemical localization of the GABAc receptor rho subunits in the mammalian retina","volume":"16","author":"Enz R","year":"1996","journal-title":"J Neurosci"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.83.4.1817"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-17-06776.1998"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.t01-1-00217.x"},{"key":"e_1_2_6_35_1","first-page":"103","volume-title":"Retina","author":"Frishman LJ","year":"2005"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.13.000601"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(94)00165-I"},{"key":"e_1_2_6_38_1","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1152\/jn.1987.57.5.1361","article-title":"Suppressive rod\u2013cone interaction in distal vertebrate retina: intracellular records from Xenopus and Necturus","volume":"57","author":"Frumkes TE","year":"1987","journal-title":"J Neurophysiol"},{"key":"e_1_2_6_39_1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1152\/jn.1995.74.2.856","article-title":"GABA\u2010 and glycine\u2010activated currents in the rod bipolar cell of the rabbit retina","volume":"74","author":"Gillette MA","year":"1995","journal-title":"J Neurophysiol"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6857279"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(82)90120-1"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-16-06036.2001"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.81.6.2923"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20000814)424:1<1::AID-CNE1>3.0.CO;2-V"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00526.2004"},{"key":"e_1_2_6_46_1","first-page":"2070","article-title":"The a\u2010wave of the human electroretinogram and rod receptor function","volume":"31","author":"Hood DC","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.98.2.777"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6989(79)90143-3"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0183-07.2007"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5208-04.2005"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.204.14.2439"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-02-00518.2003"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3089-03.2004"},{"key":"e_1_2_6_54_1","first-page":"997","article-title":"Tetrodotoxin, saxitoxin and their significance in the study of excitation phenomena","volume":"18","author":"Kao CY","year":"1966","journal-title":"Pharmacol Rev"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(00)00028-6"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0724"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(01)00299-9"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017551"},{"key":"e_1_2_6_59_1","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1152\/jn.1990.63.4.860","article-title":"Voltage\u2010 and transmitter\u2010gated currents in isolated rod bipolar cells of rat retina","volume":"63","author":"Karschin A","year":"1990","journal-title":"J Neurophysiol"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1385-299X(01)00076-9"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10633-005-2629-8"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016497"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800001711"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-01-00442.1999"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0042-6989(01)00214-0"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523805222010"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0291"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-1332"},{"key":"e_1_2_6_69_1","first-page":"201","volume-title":"Excitatory Amino Acids and Synaptic Transmission","author":"Massey SC","year":"1998"},{"key":"e_1_2_6_70_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1152\/jn.1987.57.3.645","article-title":"Excitatory amino acid receptors of rod\u2010 and cone\u2010driven horizontal cells in the rabbit retina","volume":"57","author":"Massey SC","year":"1987","journal-title":"J Neurophysiol"},{"key":"e_1_2_6_71_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1152\/jn.1990.63.1.16","article-title":"N\u2010Methyl\u2010D\u2010aspartate receptors of ganglion cells in rabbit retina","volume":"63","author":"Massey SC","year":"1990","journal-title":"J Neurophysiol"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3232-04.2005"},{"key":"e_1_2_6_73_1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1152\/jn.1970.33.3.323","article-title":"Intracellular responses of the Muller (glial) cells of mudpuppy retina: their relation to b\u2010wave of the electroretinogram","volume":"33","author":"Miller RF","year":"1970","journal-title":"J Neurophysiol"},{"key":"e_1_2_6_74_1","article-title":"Patch clamp analysis of voltage\u2010gated Na+ currents in human retinal bipolar cells","volume":"47","author":"Miyachi E\u2010I","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_75_1","first-page":"2163","article-title":"Voltage\u2010gated sodium channel a\u2010subunits Nav1.1, Nav1.2, and Nav1.6 in the distal mammalian retina","volume":"13","author":"Mojumder DK","year":"2007","journal-title":"Mol Vis"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523803205071"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523801184142"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.47.5.965"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(88)90025-0"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901720106"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138370"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-9071.2001.00402.x"},{"key":"e_1_2_6_83_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.12.002259"},{"key":"e_1_2_6_84_1","doi-asserted-by":"publisher","DOI":"10.1562\/2006-06-15-RA-923"},{"key":"e_1_2_6_85_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1990.tb19217.x"},{"key":"e_1_2_6_86_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.5.2564"},{"key":"e_1_2_6_87_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800000031"},{"key":"e_1_2_6_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00469.x"},{"key":"e_1_2_6_89_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1152\/jn.1990.64.2.313","article-title":"Background\u2010induced flicker enhancement in cat retinal horizontal cells. I. Temporal and spectral properties","volume":"64","author":"Pflug R","year":"1990","journal-title":"J Neurophysiol"},{"key":"e_1_2_6_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00839.2004"},{"key":"e_1_2_6_91_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-0458"},{"key":"e_1_2_6_92_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0009"},{"key":"e_1_2_6_93_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0218"},{"key":"e_1_2_6_94_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.05-1051"},{"key":"e_1_2_6_95_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800009408"},{"key":"e_1_2_6_96_1","doi-asserted-by":"publisher","DOI":"10.1364\/JOSAA.13.000613"},{"key":"e_1_2_6_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2004.09.002"},{"key":"e_1_2_6_98_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.030304"},{"key":"e_1_2_6_99_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-09-03451.1998"},{"key":"e_1_2_6_100_1","article-title":"A TTX\u2010sensitive Na+\u2010current in one type of ON bipolar cell in the ground squirrel retina","volume":"46","author":"Saszik SM","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_101_1","article-title":"Effect of the rod\u2010driven electroretinogram of eliminating Connexin\u201036 from the mouse retina","author":"Saszik SM","year":"2002","journal-title":"Abstr Soc Neurosci"},{"key":"e_1_2_6_102_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.019703"},{"key":"e_1_2_6_103_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7754386"},{"key":"e_1_2_6_104_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523805225129"},{"key":"e_1_2_6_105_1","first-page":"219","article-title":"The structure and development of the rat retina: an immunofluorescence microscopical study using antibodies specific for intermediate filament proteins","volume":"30","author":"Shaw G","year":"1983","journal-title":"Eur J Cell Biol"},{"key":"e_1_2_6_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-7-54"},{"key":"e_1_2_6_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10838"},{"key":"e_1_2_6_108_1","first-page":"673","article-title":"Differential distribution of vesicle associated membrane protein isoforms in the mouse retina","volume":"9","author":"Sherry DM","year":"2003","journal-title":"Mol Vis"},{"key":"e_1_2_6_109_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800002431"},{"key":"e_1_2_6_110_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-01-00313.1993"},{"key":"e_1_2_6_111_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-12-03505.1986"},{"key":"e_1_2_6_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80560-7"},{"key":"e_1_2_6_113_1","first-page":"3084","article-title":"Optic nerve and peripapillary choroidal microvasculature of the rat eye","volume":"40","author":"Sugiyama K","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0479p.x"},{"key":"e_1_2_6_115_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523899162187"},{"key":"e_1_2_6_116_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5646-06.2007"},{"key":"e_1_2_6_117_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-21-08616.2001"},{"key":"e_1_2_6_118_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1992.68.4.1143"},{"key":"e_1_2_6_119_1","first-page":"2797","article-title":"The uniform field and pattern ERG in macaques with experimental glaucoma: removal of spiking activity","volume":"41","author":"Viswanathan S","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_120_1","first-page":"1124","article-title":"The photopic negative response of the macaque electroretinogram: reduction by experimental glaucoma","volume":"40","author":"Viswanathan S","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_121_1","first-page":"514","article-title":"The photopic negative response of the flash electroretinogram in primary open angle glaucoma","volume":"42","author":"Viswanathan S","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902480103"},{"key":"e_1_2_6_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(98)00006-8"},{"key":"e_1_2_6_124_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1017549415254"},{"key":"e_1_2_6_125_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.10139"},{"key":"e_1_2_6_126_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-07-04762.1995"},{"key":"e_1_2_6_127_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523803203084"},{"key":"e_1_2_6_128_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.1.96"},{"key":"e_1_2_6_129_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-13-04543.2001"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2008.150755","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2008.150755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T09:58:46Z","timestamp":1697277526000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2008.150755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5,15]]},"references-count":128,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,5,15]]}},"alternative-id":["10.1113\/jphysiol.2008.150755"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2008.150755","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5,15]]}}}