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In the present study we investigated if the stretch induced by a balloon at this site inhibits a rapid onset salt appetite, and if this procedure modifies the pattern of immunohistochemical labelling for Fos protein (Fos\u2010ir) in the brain. Male Sprague\u2013Dawley rats with SVC\u2010RAJ balloons received a combined treatment of furosemide (Furo; 10 mg (kg bw)<jats:sup>\u22121<\/jats:sup>) plus a low dose of the angiotensin\u2010converting enzyme inhibitor captopril (Cap; 5 mg (kg bw)<jats:sup>\u22121<\/jats:sup>). Balloon inflation greatly decreased the intake of 0.3 <jats:sc>m<\/jats:sc> NaCl for as long as the balloon was inflated. Balloon inflation over a 3 h period following Furo\u2013Cap treatment decreased Fos\u2010ir in the organum vasculosum of the lamina terminalis and the subfornical organ and increased Fos\u2010ir in the lateral parabrachial nucleus and caudal ventrolateral medulla. The effect of balloon inflation was specific for sodium intake because it did not affect the drinking of diluted sweetened condensed milk. Balloon inflation and deflation also did not acutely change mean arterial pressure. These results suggest that activity in forebrain circumventricular organs and in hindbrain putative body fluid\/cardiovascular regulatory regions is affected by loading low pressure mechanoreceptors at the SVC\u2010RAJ, a manipulation that also attenuates salt appetite.<\/jats:p>","DOI":"10.1113\/jphysiol.2008.151282","type":"journal-article","created":{"date-parts":[[2008,6,13]],"date-time":"2008-06-13T01:54:19Z","timestamp":1213322059000},"page":"3719-3729","source":"Crossref","is-referenced-by-count":22,"title":["Right atrial stretch alters fore\u2010 and hind\u2010brain expression of <i>c\u2010fos<\/i> and inhibits the rapid onset of salt appetite"],"prefix":"10.1113","volume":"586","author":[{"given":"Juliana Irani Fratucci","family":"De Gobbi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Vanderlei","family":"Menani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terry 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