{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:42:42Z","timestamp":1791312162555,"version":"4.3.1"},"reference-count":77,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2008,9,10]],"date-time":"2008-09-10T00:00:00Z","timestamp":1221004800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>Neural plasticity occurs throughout adult life in response to maturation, use and disuse. Recent studies have documented that H\u2010reflex amplitudes increase following a period of immobilization. To elucidate the mechanisms contributing to the increase in H\u2010reflex size following immobilization we immobilized the left foot and ankle joint for 2 weeks in 12 able\u2010bodied subjects. Disynaptic reciprocal inhibition of soleus (SOL) motoneurons and presynaptic control of SOL group Ia afferents was measured before and after the immobilization as well as following 2 weeks of recovery. Following immobilization, maximal voluntary plantar\u2010 and dorsiflexion torque (MVC) was significantly reduced and the maximal SOL H\u2010reflex amplitude increased with no changes in the maximal compound motor response (M<jats:sub>max<\/jats:sub>). Decreased presynaptic inhibition of the Ia afferents probably contributed to the increase of the H\u2010reflex size, since we observed a significant decrease in the long\u2010latency depression of the SOL H\u2010reflex evoked by peroneal nerve stimulation (D2 inhibition) and an increase in the size of the monosynaptic Ia facilitation of the SOL H\u2010reflex evoked by femoral nerve stimulation. These two measures provide independent evidence of changes in presynaptic inhibition of SOL Ia afferents and taken together suggest that GABAergic presynaptic inhibition of the SOL Ia afferents is decreased following 2 weeks of immobilization. The depression of the SOL H\u2010reflex when evoked at intervals shorter than 10 s (homosynaptic post\u2010activation depression) also decreased following immobilization, suggesting that the activity\u2010dependent regulation of transmitter release from the afferents was also affected by immobilization. We observed no significant changes in disynaptic reciprocal Ia inhibition. Two weeks after cast removal measurements returned to pre\u2010immobilization levels. Together, these observations suggest that disuse causes plastic changes in spinal interneuronal circuitries responsible for presynaptic control of sensory input to the spinal cord. This may be of significance for the motor disabilities seen following immobilization as well as the development of spasticity following central motor lesions.<\/jats:p>","DOI":"10.1113\/jphysiol.2008.156547","type":"journal-article","created":{"date-parts":[[2008,7,4]],"date-time":"2008-07-04T00:34:16Z","timestamp":1215131656000},"page":"4121-4135","source":"Crossref","is-referenced-by-count":101,"title":["Immobilization induces changes in presynaptic control of group Ia afferents in healthy humans"],"prefix":"10.1113","volume":"586","author":[{"given":"Jesper","family":"Lundbye\u2010Jensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens 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