{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:18:11Z","timestamp":1767838691424,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2008,10,14]],"date-time":"2008-10-14T00:00:00Z","timestamp":1223942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2008,10,15]]},"abstract":"<jats:p>We investigated intracellular Ca<jats:sup>2+<\/jats:sup>waves, spontaneous transient outward currents (STOCs), and membrane potentials of gastric antrum smooth muscle cells from wild\u2010type and phospholamban\u2010knockout mice. The NO donor sodium nitroprusside (SNP) increased intracellular Ca<jats:sup>2+<\/jats:sup>wave activity in wild\u2010type antrum smooth muscle cells, but had no effect on the constitutively elevated intracellular Ca<jats:sup>2+<\/jats:sup>wave activity of phospholamban\u2010knockout cells. STOC activity was also constitutively elevated in phospholamban\u2010knockout antrum smooth muscle cells relative to wild\u2010type cells. SNP or 8\u2010bromo\u2010cGMP increased the STOC activity of wild\u2010type antrum smooth muscle cells, but had no effect on STOC activity of phospholamban\u2010knockout cells. Iberiotoxin, but not apamin, inhibited STOC activity in wild\u2010type and phospholamban\u2010knockout antrum smooth muscle cells. In the presence of SNP, STOC activity in wild\u2010type and phospholamban\u2010knockout antrum smooth muscle cells was inhibited by ryanodine, but not 2\u2010APB. The cGMP\u2010dependent protein kinase inhibitor KT5823 reversed the increase in STOC activity evoked by SNP in wild\u2010type antrum smooth muscle cells, but had no effect on STOC activity in phospholamban\u2010knockout cells. The resting membrane potential of phospholamban\u2010knockout antrum smooth muscle cells was hyperpolarized by approximately \u22126 mV compared to wild\u2010type cells. SNP hyperpolarized the resting membrane potential of wild\u2010type antrum smooth muscle cells to a greater extent than phospholamban\u2010knockout antrum smooth muscles. Despite the hyperpolarized membrane potential, slow wave activity was significantly increased in phospholamban\u2010knockout antrum smooth muscles compared to wild\u2010type smooth muscles. These results suggest that phospholamban is an important component of the mechanisms regulating the electrical properties of gastric antrum smooth muscles.<\/jats:p>","DOI":"10.1113\/jphysiol.2008.156836","type":"journal-article","created":{"date-parts":[[2008,10,14]],"date-time":"2008-10-14T17:29:22Z","timestamp":1224005362000},"page":"4977-4991","source":"Crossref","is-referenced-by-count":5,"title":["Modulation of murine gastric antrum smooth muscle STOC activity and excitability by phospholamban"],"prefix":"10.1113","volume":"586","author":[{"given":"Minkyung","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant W.","family":"Hennig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungsik","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In 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