{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:33:08Z","timestamp":1792045988880,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2008,10,30]],"date-time":"2008-10-30T00:00:00Z","timestamp":1225324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>Patients with inflammatory bowel disease often suffer from gastrointestinal motility and sensitivity disorders. The aim of the current study was to investigate the role of transient receptor potential of the vanilloid type 1 (TRPV1) receptors in the pathophysiology of colitis\u2010induced pelvic afferent nerve sensitization. Trinitrobenzene sulphate (TNBS) colitis (7.5 mg, 30% ethanol) was induced in Wistar rats 72 h prior to the experiment. Single\u2010fibre recordings were made from pelvic nerve afferents in the decentralized S1 dorsal root. Fibres responding to colorectal distension (CRD) were identified in controls and rats with TNBS colitis. The effect of the TRPV1 antagonist <jats:italic>N<\/jats:italic>\u2010(4\u2010tertiarybutylphenyl)\u20104\u2010(3\u2010chlorophyridin\u20102\u2010yl)tetrahydropyrazine\u20101(2H)carboxamide (BCTC; 0.25\u20135 mg kg<jats:sup>\u22121<\/jats:sup>) or its vehicle (hydroxypropyl\u2010\u03b2\u2010cyclodextrin) was tested on the afferent response to repetitive distensions (60 mmHg). Immunocytochemical staining of TRPV1 and NF200, a marker for A\u2010fibre neurons, was performed in the dorsal root ganglia L6\u2013S1. TNBS colitis significantly increased the response to colorectal distension of pelvic afferent C\u2010fibres. BCTC did not significantly affect the C\u2010fibre response in controls, but normalized the sensitized response in rats with colitis. TNBS colitis increased the spontaneous activity of C\u2010fibres, an effect which was insensitive to administration of BCTC. TNBS colitis had no effect on A\u03b4\u2010fibres, nor was their activity modulated by BCTC. TNBS colitis caused an immunocytochemical up\u2010regulation of TRPV1 receptors in the cell bodies of pelvic afferent NF200 negative neurons. TRPV1 signalling mediates the colitis\u2010induced sensitization of pelvic afferent C\u2010fibres to CRD, while A\u03b4\u2010fibres are neither sensitized by colitis nor affected by TRPV1 inhibition.<\/jats:p>","DOI":"10.1113\/jphysiol.2008.159731","type":"journal-article","created":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T17:33:29Z","timestamp":1225474409000},"page":"5247-5258","source":"Crossref","is-referenced-by-count":55,"title":["TRPV1 receptors on unmyelinated C\u2010fibres mediate colitis\u2010induced sensitization of pelvic afferent nerve fibres in rats"],"prefix":"10.1113","volume":"586","author":[{"given":"H. U.","family":"De Schepper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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