{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:38:19Z","timestamp":1791398299070,"version":"4.3.3"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T00:00:00Z","timestamp":1240963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>\n                    Recent data from transgenic mice suggest that orexin plays an important role in the ventilatory response to CO\n                    <jats:sub>2<\/jats:sub>\n                    during wakefulness. We hypothesized that orexin receptor\u20101 (OX\n                    <jats:sub>1<\/jats:sub>\n                    R) in the retrotrapezoid nucleus (RTN) contributes to chemoreception. In unanaesthetized rats, we measured ventilation using a whole\u2010body plethysmograph, together with EEG and EMG. We dialysed the vehicle and then SB\u2010334867 (OX\n                    <jats:sub>1<\/jats:sub>\n                    R antagonist) into the RTN to focally inhibit OX\n                    <jats:sub>1<\/jats:sub>\n                    R and studied the effects of both treatments on breathing in air and in 7% CO\n                    <jats:sub>2<\/jats:sub>\n                    . During wakefulness, SB\u2010334867 caused a 30% reduction of the hyperventilation induced by 7% CO\n                    <jats:sub>2<\/jats:sub>\n                    (mean \u00b1 S.E.M., 135 \u00b1 10 ml (100 g)\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) compared with vehicle (182 \u00b1 10 ml (100 g)\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01). This effect was due to both decreased tidal volume and breathing frequency. There was a much smaller, though significant, effect in sleep (9% reduction). Neither basal ventilation nor oxygen consumption was affected. The number and duration of apnoeas were similar between control and treatment periods. No effect was observed in a separate group of animals who had the microdialysis probe misplaced (peri\u2010RTN). We conclude that projections of orexin\u2010containing neurons to the RTN contribute, via OX\n                    <jats:sub>1<\/jats:sub>\n                    Rs in the region, to the hypercapnic chemoreflex control during wakefulness and to a lesser extent, non\u2010rapid eye movement sleep.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2008.168260","type":"journal-article","created":{"date-parts":[[2009,3,9]],"date-time":"2009-03-09T21:06:49Z","timestamp":1236632809000},"page":"2059-2067","source":"Crossref","is-referenced-by-count":96,"title":["Antagonism of orexin receptor\u20101 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness"],"prefix":"10.1113","volume":"587","author":[{"given":"Mirela Barros","family":"Dias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene E.","family":"Nattie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(70)90056-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00719.2002"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.08.008"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.1.322"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00075.2007"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00120.2008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2007.06.004"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00319-0"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-05-01656.2001"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(01)02318-6"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0b013e32831311d3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-13-05282.2002"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00997-1"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1887-05.2005"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.3.910"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.04.035"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00679.2006"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01336-0"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01128.2001"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.020032"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-3-28"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2007.08.001"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209532200"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00968.2002"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-23-09996.1998"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80949-6"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.02.058"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399408000823"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702676104"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00914.2004"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.05.032"}],"container-title":["The 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