{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:25:18Z","timestamp":1791498318031,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2009,4,15]]},"abstract":"<jats:p>\n                    Auditory afferent fibre activity in mammals relies on neurotransmission at hair cell ribbon synapses. Developmental changes in the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    sensitivity of the synaptic machinery allow inner hair cells (IHCs), the primary auditory receptors, to encode Ca\n                    <jats:sup>2+<\/jats:sup>\n                    action potentials (APs) during pre\u2010hearing stages and graded receptor potentials in adult animals. However, little is known about the time course of these changes or whether the kinetic properties of exocytosis differ as a function of IHC position along the immature cochlea. Furthermore, the role of afferent transmission in outer hair cells (OHCs) is not understood. Calcium currents and exocytosis (measured as membrane capacitance changes: \u0394\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>m<\/jats:sub>\n                    ) were measured with whole\u2010cell recordings from immature gerbil hair cells using near\u2010physiological conditions. The kinetics, vesicle pool depletion and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    coupling of exocytosis were similar in apical and basal immature IHCs. This could indicate that possible differences in AP activity along the immature cochlea do not require synaptic specialization. Neurotransmission in IHCs became mature from postnatal day 20 (P20), although changes in its Ca\n                    <jats:sup>2+<\/jats:sup>\n                    dependence occurred at P9\u2013P12 in basal and P12\u2013P15 in apical cells. OHCs showed a smaller \u0394\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>m<\/jats:sub>\n                    than IHCs that was reflected by fewer active zones in OHCs. Otoferlin, the proposed Ca\n                    <jats:sup>2+<\/jats:sup>\n                    sensor in cochlear hair cells, was similarly distributed in both cell types despite the high\u2010order exocytotic Ca\n                    <jats:sup>2+<\/jats:sup>\n                    dependence in IHCs and the near\u2010linear relation in OHCs. The results presented here provide a comprehensive study of the function and development of hair cell ribbon synapses.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2009.168542","type":"journal-article","created":{"date-parts":[[2009,2,23]],"date-time":"2009-02-23T20:24:25Z","timestamp":1235420665000},"page":"1715-1726","source":"Crossref","is-referenced-by-count":50,"title":["Functional maturation of the exocytotic machinery at gerbil hair cell ribbon synapses"],"prefix":"10.1113","volume":"587","author":[{"given":"Stuart 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