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Loss of myostatin induced eccentric hypertrophy and enhanced cardiac responsiveness to \u03b2\u2010adrenergic stimulation <jats:italic>in vivo<\/jats:italic>. This was due to myostatin null ventricular myocytes having larger [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> transients and contractions and responding more strongly to \u03b2\u2010adrenergic stimulation than wild\u2010type cells. Enhanced cardiac output and \u03b2\u2010adrenergic responsiveness of myostatin null mice was therefore due to increased SR Ca<jats:sup>2+<\/jats:sup> release during EC coupling and to physiological hypertrophy, but not to enhanced myofilament function as determined by simultaneous measurement of force and ATPase activity. Our studies support the novel concept that myostatin is a repressor of physiological cardiac muscle growth and function. Thus, the controlled inhibition of myostatin action could potentially help repair damaged cardiac muscle by inducing physiological hypertrophy.<\/jats:p>","DOI":"10.1113\/jphysiol.2009.172544","type":"journal-article","created":{"date-parts":[[2009,9,8]],"date-time":"2009-09-08T01:08:56Z","timestamp":1252372136000},"page":"4873-4886","source":"Crossref","is-referenced-by-count":62,"title":["Myostatin represses physiological hypertrophy of the heart and excitation\u2013contraction coupling"],"prefix":"10.1113","volume":"587","author":[{"given":"Buel D.","family":"Rodgers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian P.","family":"Interlichia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilip K.","family":"Garikipati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranganath","family":"Mamidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O. 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