{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:08:05Z","timestamp":1792714085351,"version":"4.5.0"},"reference-count":70,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2009,11,30]],"date-time":"2009-11-30T00:00:00Z","timestamp":1259539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>Two major issues are presented. First, a challenge is made by us that a misunderstanding of physiology has led to incomplete or wrong functional designations of genes in some cases. Normal physiological processes are dynamic, integrated and periodic, and, therefore, it is difficult to define normal physiological function by looking at a single time point or single process in a non\u2010stressed subject. The ability of the organism to successfully respond to homeostatic disruptions defines normal physiology. Genes were selected for survival and to appropriately respond to stresses, such as physical activity. Omitting gene functions by restricting them to non\u2010stressful conditions could lead to less than optimal primary preventions, treatments and cures for diseases. Physical exercise, as a stressor, should be used to better demonstrate the complete functional classifications of some genes. Second, the challenge from others of an \u2018exercise pill\u2019 as a mimetic of natural physical activity will be shown to be lacking a scientific basis. The concept of an \u2018exercise pill\u2019\/\u2018exercise mimetic\u2019 demonstrates an inadequate appreciation of the complexities in integrating cell, tissue, organ and systems during both acute disruptions in homeostasis by a single bout of exercise, and longer\u2010term chronic adaptations to different types of exercise such as resistance and endurance. It is our opinion that those promoting drugs targeting a single or few molecules should not redefine the term \u2018exercise\u2019 and exercise concepts in an attempt to sensationalize findings. Additionally, the scientific criteria that the authors demand to be met to legitimately use the terms \u2018exercise pill\u2019 and \u2018exercise mimetic\u2019 are presented.<\/jats:p>","DOI":"10.1113\/jphysiol.2009.179507","type":"journal-article","created":{"date-parts":[[2009,9,2]],"date-time":"2009-09-02T02:24:25Z","timestamp":1251858265000},"page":"5527-5539","source":"Crossref","is-referenced-by-count":89,"title":["Lack of adequate appreciation of physical exercise's complexities can pre\u2010empt appropriate design and interpretation in scientific discovery"],"prefix":"10.1113","volume":"587","author":[{"given":"F. W.","family":"Booth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Laye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,11,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.493968"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00188.2002"},{"key":"e_1_2_6_4_1","first-page":"1075","volume-title":"Handbook of Physiology: section 12, Exercise: Regulation and Integration of Multiple Systems","author":"Booth FW","year":"1996"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00073.2002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.2.774"},{"key":"e_1_2_6_7_1","article-title":"Gold standards for scientists who are conducting animal\u2010based exercise studies","author":"Booth FW","year":"2009","journal-title":"J Appl Physiol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00174.2006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1420-x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gln031"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00757.2003"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00545.2005"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2008.053850"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2005.06.003"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-971926"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0448"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-6296(02)00126-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1215\/03616878-2007-063"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00282.2007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0266462307051598"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1204"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195108248.001.0001","volume-title":"Cost\u2010effectiveness in Health and Medicine","author":"Gold MR","year":"1996"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcibr0806723"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.271.2.E403"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-109686"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1081\/ERC-200043759"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2009.00185.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802842"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01137"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.38.030176.001421"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81865-6"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-008-0006-0"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3144fje"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1139\/h04-008"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11559"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00085.2007"},{"key":"e_1_2_6_37_1","volume-title":"The Structure of Scientific Revolutions","author":"Kuhn TS","year":"1962"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.073593"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00666.2007"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1215\/03616878-2007-036"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/109502"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01371.2007"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.10.B359"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312023292301"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01034.2007"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.051"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.1.72"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.11.1259"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00257.2006"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.949bp.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.047233"},{"key":"e_1_2_6_52_1","volume-title":"Physical Activity Guidelines Advisory Committee Report","author":"Physical Activity Guidelines Advisory Committee","year":"2008"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-4-200902170-00005"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.3810\/psm.2000.10.1237"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2002-0012"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00121.2009"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00872.2007"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00500.2007"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.09.005"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00428.2007"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.07.004"},{"key":"e_1_2_6_62_1","unstructured":"Salk Institute for Biological Studies. Scientific Report2008. pp.26\u201327http:\/\/www.salk.edu\/pdf\/scientific_report\/scientific_report08.pdf"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60801-6"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31818c6be9"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04684.x"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.181485"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1982.03320430039028"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199505000-00005"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2008.053512"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071163"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1417"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2009.179507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2009.179507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:29:20Z","timestamp":1710570560000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2009.179507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,30]]},"references-count":70,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1113\/jphysiol.2009.179507"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2009.179507","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,30]]}}}