{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:25:13Z","timestamp":1769732713058,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2010,6,29]],"date-time":"2010-06-29T00:00:00Z","timestamp":1277769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:p>Myocardial hypertrophy and dysfunction occur in response to excessive catecholaminergic drive. Adverse cardiac remodelling is associated with activation of proinflammatory cytokines in the myocardium. To test the hypothesis that exercise training can prevent myocardial dysfunction and production of proinflammatory cytokines induced by \u03b2\u2010adrenergic hyperactivity, male Wistar rats were assigned to one of the following four groups: sedentary non\u2010treated (Con); sedentary isoprenaline treated (Iso); exercised non\u2010treated (Ex); and exercised plus isoprenaline (Iso+Ex). Echocardiography, haemodynamic measurements and isolated papillary muscle were used for functional evaluations. Real\u2010time RT\u2010PCR and Western blot were used to quantify tumour necrosis factor \u03b1, interleukin\u20106, interleukin\u201010 and transforming growth factor \u03b2<jats:sub>1<\/jats:sub> (TGF\u2010\u03b2<jats:sub>1<\/jats:sub>) in the tissue. NF\u2010\u03baB expression in the nucleus was evaluated by immunohistochemical staining. The Iso rats showed a concentric hypertrophy of the left ventricle (LV). These animals exhibited marked increases in LV end\u2010diastolic pressure and impaired myocardial performance <jats:italic>in vitro<\/jats:italic>, with a reduction in the developed tension and maximal rate of tension increase and decrease, as well as worsened recruitment of the Frank\u2013Starling mechanism. Both gene and protein levels of tumour necrosis factor \u03b1 and interleukin\u20106, as well as TGF\u2010\u03b2<jats:sub>1<\/jats:sub> mRNA, were increased. In addition, the NF\u2010\u03baB expression in the Iso group was significantly raised. In the Iso+Ex group, the exercise training had the following effects: (1) it prevented LV hypertrophy; (ii) it improved myocardial contractility; (3) it avoided the increase of proinflammatory cytokines and improved interleukin\u201010 levels; and (4) it attenuated the increase of TGF\u2010\u03b2<jats:sub>1<\/jats:sub> mRNA. Thus, exercise training in a model of \u03b2\u2010adrenergic hyperactivity can avoid the adverse remodelling of the LV and inhibit inflammatory cytokines. Moreover, the cardioprotection is related to beneficial effects on myocardial performance.<\/jats:p>","DOI":"10.1113\/jphysiol.2010.187310","type":"journal-article","created":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T02:04:05Z","timestamp":1273025045000},"page":"2431-2442","source":"Crossref","is-referenced-by-count":53,"title":["Exercise training inhibits inflammatory cytokines and more than prevents myocardial dysfunction in rats with sustained \u03b2\u2010adrenergic hyperactivity"],"prefix":"10.1113","volume":"588","author":[{"given":"Andrey J.","family":"Serra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia H. 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