{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:23:34Z","timestamp":1791091414447,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T00:00:00Z","timestamp":1297987200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2011,2,15]]},"abstract":"<jats:p>\n                    <jats:bold>Non\u2010technical summary<\/jats:bold>\n                    Patients suffering from obstructive sleep apnoea (OSA) experience repeated decreases in blood oxygen (hypoxia) and increases in CO\n                    <jats:sub>2<\/jats:sub>\n                    (hypercapnia) causing sleep disruption, cardiac over\u2010stimulation, intense vasoconstriction and, eventually, day\u2010time hypertension. Hypoxia and hypercapnia initiate these responses by activating the carotid bodies whereas hypercapnia also works in the central nervous system. In this study in anaesthetized rats we show that a group of noradrenergic neurons located in the lower brainstem (A5 neurons) are vigorously activated by carotid body stimulation and mildly affected by CO\n                    <jats:sub>2<\/jats:sub>\n                    . We also show that selective activation of the A5 neurons increases sympathetic tone to the viscera and we suggest that these catecholaminergic neurons contribute to the cardiovascular stimulation caused by acute hypoxia. The importance of the A5 neurons to acute hypoxic responses in the conscious state remains to be assessed and their contribution to the day\u2010time hypertension associated with OSA is also a matter for future research.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2010.198374","type":"journal-article","created":{"date-parts":[[2010,12,21]],"date-time":"2010-12-21T00:50:52Z","timestamp":1292892652000},"page":"903-917","source":"Crossref","is-referenced-by-count":48,"title":["Regulation of visceral sympathetic tone by A5 noradrenergic neurons in rodents"],"prefix":"10.1113","volume":"589","author":[{"given":"Roy","family":"Kanbar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth D.","family":"Depuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin 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