{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:25:57Z","timestamp":1790519157116,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,3,14]],"date-time":"2011-03-14T00:00:00Z","timestamp":1300060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2011,3,15]]},"abstract":"<jats:p>\n                    <jats:bold>Non\u2010technical summary\u2002<\/jats:bold>\n                    Acute intermittent hypoxia elicits a serotonin\u2010dependent form of respiratory plasticity known as phrenic long\u2010term facilitation\n                    <jats:italic>via<\/jats:italic>\n                    synthesis of brain\u2010derived neurotrophic factor (BDNF) and activation of its receptor TrkB. Recently we demonstrated that spinal activation of Gs protein\u2010coupled adenosine A2A receptors \u2018trans\u2010activates\u2019 the BDNF receptor, TrkB, and induces phrenic motor facilitation (PMF). Therefore we hypothesized that perhaps other Gs protein\u2010coupled serotonin receptors elicit PMF, specifically serotonin receptor type\u20107 (5\u2010HT7) which are expressed in phrenic motor neurons and underlie multiple forms of spinal respiratory plasticity. We demonstrate that spinal 5\u2010HT7 receptor activation in anaesthetized rats elicits long\u2010lasting PMF. 5\u2010HT7 agonist\u2010induced PMF appears to require TrkB receptor activity and\/or new synthesis of TrkB protein, in addition to activity of the signalling molecule PI3K. A more complete understanding of signalling mechanisms involved in PMF may guide development of novel therapeutic strategies to treat ventilatory control disorders.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2010.201657","type":"journal-article","created":{"date-parts":[[2011,1,17]],"date-time":"2011-01-17T22:36:11Z","timestamp":1295303771000},"page":"1397-1407","source":"Crossref","is-referenced-by-count":83,"title":["Spinal 5\u2010HT7 receptor activation induces long\u2010lasting phrenic motor facilitation"],"prefix":"10.1113","volume":"589","author":[{"given":"M. S.","family":"Hoffman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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