{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:21:55Z","timestamp":1791901315057,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T00:00:00Z","timestamp":1297987200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2011,2,15]]},"abstract":"<jats:p><jats:bold>Non\u2010technical summary<\/jats:bold> Activation of apoptotic cell death signalling by mitochondria is involved in mediating skeletal muscle atrophy following denervation. However, the underlying molecular mechanisms remain unclear, in particular the role of the permeability transition pore (PTP), a high conductance non specific channel of the mitochondrial inner membrane involved in cell death. Using <jats:italic>Ppif<jats:sup>\u2212\/\u2212<\/jats:sup><\/jats:italic> mice, which are devoid of the PTP sensitizing protein cyclophilin\u2010D and thus more resistant to pore opening, we directly tested the hypothesis that this pore is involved in atrophy and activation of apoptotic proteolytic signalling following denervation. Our results demonstrate that cyclophilin\u2010D, and by extension opening of the PTP, is dispensable for atrophy and activation of apoptotic proteolytic signalling induced by denervation.<\/jats:p>","DOI":"10.1113\/jphysiol.2010.202036","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T01:39:03Z","timestamp":1294191543000},"page":"855-861","source":"Crossref","is-referenced-by-count":6,"title":["Cyclophilin\u2010D is dispensable for atrophy and mitochondrial apoptotic signalling in denervated muscle"],"prefix":"10.1113","volume":"589","author":[{"given":"Frederic N.","family":"Daussin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Godin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Ascah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Desch\u00eanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Burelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.3109\/10715761003692487","article-title":"Oxidative stress in the denervated muscle","volume":"44","author":"Abruzzo PM","journal-title":"Free Radic Res"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00768.2006"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610270104"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl061"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03434"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C500089200"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806311200"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00050a027"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3410233"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000148632.35500.d9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.109702"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.167387"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1960663"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.05.007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1736"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03317"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31060"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp126"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200807-1005OC"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505294102"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.081083"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-006-6315-4"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(02)00030-5"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2009.98"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4157(95)00003-A"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2010.202036","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2010.202036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T04:02:42Z","timestamp":1697256162000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2010.202036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,15]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,2,15]]}},"alternative-id":["10.1113\/jphysiol.2010.202036"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2010.202036","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,15]]}}}