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In the present study we interfered with intracellular calcium signalling in astrocytes in mouse somatosensory cortex by dialysis with the calcium chelator BAPTA. Such treatment increased excitability of the nearby neurons. The effect of astrocytic calcium chelation was mimicked by pharmacological inhibition of GABA receptors, suggesting that this control is GABA mediated through a combined involvement of GABA<jats:sub>A<\/jats:sub> and GABA<jats:sub>B<\/jats:sub> receptors. This finding demonstrates a role for astrocytes in the regulation of neural inhibition in somatosensory (barrel) cortex and adds a new variant to the growing number of pathways by which astrocytes can modulate neuronal networks.<\/jats:p>","DOI":"10.1113\/jphysiol.2010.203224","type":"journal-article","created":{"date-parts":[[2011,1,11]],"date-time":"2011-01-11T03:55:07Z","timestamp":1294718107000},"page":"1159-1172","source":"Crossref","is-referenced-by-count":44,"title":["Astrocytes control GABAergic inhibition of neurons in the mouse barrel 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