{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:38:30Z","timestamp":1791214710618,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T00:00:00Z","timestamp":1301443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>\n                    <jats:bold>Non\u2010technical summary\u2002<\/jats:bold>\n                    Hypertrophy of skeletal muscle in response to resistance exercise is associated with significantly elevated rates of protein synthesis. The protein kinase mTORC1 has been shown to be a key signalling hub through which different anabolic factors (i.e. growth factors, nutrients and mechanical strain) contribute to the regulation of protein synthesis. In this study, we use an\n                    <jats:italic>in vivo<\/jats:italic>\n                    model of muscle hypertrophy to delineate the contribution of different input pathways regulating mTORC1. We found that the insulin\/insulin like growth factor 1 pathway is not necessary for early activation of mTORC1 signalling but this probably occurs through activation of the ERK\/TSC2 pathway. Knowledge of the key upstream pathways that modulate mTORC1 activity\n                    <jats:italic>in vivo<\/jats:italic>\n                    will provide the necessary foundation for the development of new therapeutic strategies for the maintenance of skeletal muscle mass.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2011.205658","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T00:18:49Z","timestamp":1297124329000},"page":"1831-1846","source":"Crossref","is-referenced-by-count":171,"title":["Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3\u2010kinase\/Akt signalling"],"prefix":"10.1113","volume":"589","author":[{"given":"Mitsunori","family":"Miyazaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Fedele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyn A.","family":"Esser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.6.2509"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.5.1705"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.5.1716"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2509"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1999.276.1.C120"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409143102"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1101-1014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/377441a0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5322.99"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-10-1-68"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"E89","DOI":"10.1152\/ajpendo.1990.259.1.E89","article-title":"Activation of insulin\u2010like growth factor gene expression during work\u2010induced skeletal muscle growth","volume":"259","author":"DeVol DL","year":"1990","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.163816"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.domaniend.2006.11.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1152\/jappl.2001.90.3.1166","article-title":"Selected contribution: IGF\u2010I antibody prevents increases in protein synthesis in epitrochlearis muscles from refed, diabetic rats","volume":"90","author":"Fedele MJ","year":"2001","journal-title":"J Appl Physiol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00089.2007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.04.018"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1967.213.5.1193"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E10-05-0454"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjr.0000173106.68485.b7"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj20040274"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2680231"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080281"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1110003"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb839"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1200107"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1018"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413732200"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.21.9295-9304.2004"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.051011"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.02.031"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4798"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00932.2006"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3181\/0808-RM-251"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91355.2008"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00464.2008"},{"key":"e_1_2_6_37_1","first-page":"751","article-title":"Contribution of the calcineurin signaling pathway to overload\u2010induced skeletal muscle fiber\u2010type transition","volume":"55","author":"Miyazaki M","year":"2004","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07635.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.5.1936"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00165.2005"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90874.2008"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.173609"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.8.3112-3124.2004"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1101-1009"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700906200"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.03.003"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.12.7088"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1139\/H09-010"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.141507"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.21.13150"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00049.2002"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.05.003"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7324"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2011.205658","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2011.205658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T18:01:44Z","timestamp":1698775304000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2011.205658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,30]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["10.1113\/jphysiol.2011.205658"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2011.205658","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,30]]}}}