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Under physiological conditions dopamine neurons can generate a burst of activity that seems to require NMDA receptors and that is activated by high frequency glutamatergic inputs. Here, we show in a brain slice preparation of mice that NMDA receptor activation further excites the neurons by recruiting a calcium\u2010activated non\u2010selective cation current (<jats:italic>I<\/jats:italic><jats:sub>CAN<\/jats:sub>) and we hypothesize that<jats:italic>I<\/jats:italic><jats:sub>CAN<\/jats:sub>is specifically mediated by a transient receptor potential (TRP) channel. We used RT\u2010PCR methods to confirm expression of TRPM2 and TRPM4 mRNA in substantia nigra pars compacta. We propose that<jats:italic>I<\/jats:italic><jats:sub>CAN<\/jats:sub>is selectively activated during burst firing to boost NMDA currents and allow plateau potentials. This boost mechanism may render DA cells vulnerable to excitotoxicity.<\/jats:p>","DOI":"10.1113\/jphysiol.2011.206631","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T04:34:15Z","timestamp":1300768455000},"page":"2497-2514","source":"Crossref","is-referenced-by-count":77,"title":["Calcium\u2010activated non\u2010selective cation currents are involved in generation of tonic and bursting activity in dopamine neurons of the substantia nigra pars compacta"],"prefix":"10.1113","volume":"589","author":[{"given":"Ana","family":"Mrejeru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aguan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan 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