{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:44:42Z","timestamp":1787312682492,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T00:00:00Z","timestamp":1310688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2011,7,15]]},"abstract":"<jats:p>\n                    <jats:bold>Non\u2010technical summary\u2002<\/jats:bold>\n                    The epithelial cells lining the ducts of the human mammary gland are responsible for modifying sodium and potassium concentrations in milk by actively absorbing sodium from and secreting potassium into the ductal fluid. In the present study we show that adenosine triphosphate (ATP) and uridine triphosphate (UTP) can stimulate sodium absorption and potassium secretion by a mechanism that involves increasing intracellular calcium and activation of calcium\u2010dependent potassium channels. We discovered that addition of ATP or UTP to the luminal surface stimulates potassium secretion, whereas addition of the same concentrations to the epithelial surface normally exposed to the blood produces an increase in sodium absorption. These results provide a better understanding of the signalling mechanisms that control the concentrations of sodium and potassium present in milk.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2011.207548","type":"journal-article","created":{"date-parts":[[2011,5,23]],"date-time":"2011-05-23T22:29:13Z","timestamp":1306189753000},"page":"3483-3494","source":"Crossref","is-referenced-by-count":18,"title":["K\n                    <sub>Ca<\/sub>\n                    3.1 channels facilitate K\n                    <sup>+<\/sup>\n                    secretion or Na\n                    <sup>+<\/sup>\n                    absorption depending on apical or basolateral P2Y receptor stimulation"],"prefix":"10.1113","volume":"589","author":[{"given":"Melissa L.","family":"Palmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Peitzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Maniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary C.","family":"Sieck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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