{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:04:54Z","timestamp":1791259494595,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p><jats:bold>Non\u2010technical summary\u2002<\/jats:bold> The dorsal horn of the spinal cord is the first site in the central nervous system where painful sensory information is processed before transmission to the brain. <jats:italic>In vitro<\/jats:italic> recordings in spinal slices established that this processing relies on both plasticity of synaptic connections and intrinsic electrical properties of dorsal horn neurones (DHNs). DHNs may generate plateau potentials, which underlie intense discharges and long\u2010lasting after\u2010discharges in response to a brief stimulation, and represent a putative endogenous mechanism for amplification of painful sensory inputs. Using patch\u2010clamp recordings in the anaesthetized adult rat, we show that DHNs do generate plateau potentials <jats:italic>in vivo<\/jats:italic>, which shape their responses to natural sensory stimulation. Moreover, we give direct evidence for the involvement of these amplification properties in both short\u2010term (windup) and long\u2010term sensitisation associated with neuropathic pain, raising the possibility that plateau potentials could be putative therapeutic targets to control spinal component of neuropathic pain.<\/jats:p>","DOI":"10.1113\/jphysiol.2011.207712","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T05:09:46Z","timestamp":1302584986000},"page":"2733-2743","source":"Crossref","is-referenced-by-count":27,"title":["Intrinsic membrane properties of spinal dorsal horn neurones modulate nociceptive information processing <i>in 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