{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:03:41Z","timestamp":1789506221431,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"21","license":[{"start":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T00:00:00Z","timestamp":1319760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p><jats:bold>Non\u2010Technical Summary\u2002<\/jats:bold> The debilitating condition of arthritis is caused by degeneration of the cartilage, a tissue that allows almost frictionless motion between the ends of bones in articulating joints such as the knee. The integrity of the cartilage is maintained by the metabolic activity of chondrocytes, the only type of cell found within the cartilage. An important factor in regulating the rate of metabolic activity of the chondrocytes is thought to be the magnitude of the electrical potential difference across the cell membrane, i.e. the \u2018membrane potential\u2019. This study identifies a type of ion channel, a so\u2010called \u2018two\u2010pore potassium channel\u2019, which was not previously known to be expressed in human chondrocytes. This ion channel importantly contributes to controlling chondrocyte membrane potential. Elucidation of the factors that control chondrocyte membrane potential is important for understanding the normal and pathophysiology of the chondrocytes, and consequently the health of the cartilage.<\/jats:p>","DOI":"10.1113\/jphysiol.2011.210757","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T06:44:35Z","timestamp":1315896275000},"page":"5071-5089","source":"Crossref","is-referenced-by-count":33,"title":["Two\u2010pore domain K<sup>+<\/sup> channels regulate membrane potential of isolated human articular chondrocytes"],"prefix":"10.1113","volume":"589","author":[{"given":"Robert B.","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell 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