{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:27:39Z","timestamp":1789979259026,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2011,8,15]],"date-time":"2011-08-15T00:00:00Z","timestamp":1313366400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p><jats:bold>Non\u2010technical summary\u2002<\/jats:bold> Heat stress reduces brain blood flow and impairs orthostatic tolerance. Brain blood flow is largely controlled by the partial pressure of arterial <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_4628_mu1.gif\" xlink:title=\"inline image\"\/>. Indeed, hyperthermia\u2010induced over\u2010breathing and related reductions in arterial <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_4628_mu2.gif\" xlink:title=\"inline image\"\/> account for \u223c50% of the reduction in brain blood flow. This investigation tested the unique hypothesis that the distribution of cardiac output during heat stress (challenged by thermoregulatory increases in skin blood flow and sweat loss) contributes to the remaining 50%. We show that cardiac output is not related to brain blood flow, but rather arterial <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/TJP_4628_mu3.gif\" xlink:title=\"inline image\"\/> plays a much larger role than previously suggested. These findings help us understand the mechanisms relating heat stress with an increased likelihood of fainting, and are also relevant to pathological conditions that are accompanied by elevations in body temperature.<\/jats:p>","DOI":"10.1113\/jphysiol.2011.212118","type":"journal-article","created":{"date-parts":[[2011,6,21]],"date-time":"2011-06-21T04:37:10Z","timestamp":1308631030000},"page":"4053-4064","source":"Crossref","is-referenced-by-count":92,"title":["Reductions in cerebral blood flow during passive heat stress in humans: partitioning the mechanisms"],"prefix":"10.1113","volume":"589","author":[{"given":"Michael D.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Haykowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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