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Excessive intakes that chronically increase portal and peripheral blood fructose concentrations to &gt;1 and 0.1 m<jats:sc>m<\/jats:sc>, respectively, are now associated with numerous diseases and syndromes. The role of the fructose transporters GLUT5 and GLUT2 in causing, contributing to or exacerbating these diseases is not well known. GLUT5 expression seems extremely low in neonatal intestines, and limited absorptive capacities for fructose may explain the high incidence of malabsorption in infants and cause problems in adults unable to upregulate GLUT5 levels to match fructose concentrations in the diet. GLUT5\u2010 and GLUT2\u2010mediated fructose effects on intestinal electrolyte transporters, hepatic uric acid metabolism, as well as renal and cardiomyocyte function, may play a role in fructose\u2010induced hypertension. Likewise, GLUT2 may contribute to the development of non\u2010alcoholic fatty liver disease by facilitating the uptake of fructose. Finally, GLUT5 may play a role in the atypical growth of certain cancers and fat tissues. We also highlight research areas that should yield information needed to better understand the role of these GLUTs in fructose\u2010induced diseases.<\/jats:p>","DOI":"10.1113\/jphysiol.2011.215731","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T05:44:56Z","timestamp":1352180696000},"page":"401-414","source":"Crossref","is-referenced-by-count":171,"title":["The role of fructose transporters in diseases linked to excessive fructose intake"],"prefix":"10.1113","volume":"591","author":[{"given":"Veronique","family":"Douard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo 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