{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:58:57Z","timestamp":1784937537671,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2011,10,14]],"date-time":"2011-10-14T00:00:00Z","timestamp":1318550400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2011,10,15]]},"abstract":"<jats:p><jats:bold>Non\u2010Technical Summary\u2002<\/jats:bold> The ion channel TRPM8, which is present in nerves that innervate the skin and mouth, mediates the sensation of cold temperatures and of chemical substances that evoke a cold sensation, such as menthol or eucalyptol. The molecular structures and biophysical mechanisms that allow this and related channels to integrate thermal and chemical information are poorly understood. In this work, we demonstrate that TRPM8 is able to bind up to four menthol molecules, and that every bound menthol molecule causes an equivalent stabilization of the open state of the channel. These results provide important fundamental insight into the working mechanism of temperature\u2010sensitive channels, and may assist in the development of drugs to treat oversensitivity to cold temperatures and pain.<\/jats:p>","DOI":"10.1113\/jphysiol.2011.216523","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T01:11:52Z","timestamp":1314753112000},"page":"4827-4835","source":"Crossref","is-referenced-by-count":41,"title":["Ligand stoichiometry of the cold\u2010 and menthol\u2010activated channel TRPM8"],"prefix":"10.1113","volume":"589","author":[{"given":"Annelies","family":"Janssens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Voets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,10,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1665"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/39807"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.08.038"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2004.04.010"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.110.3.257"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg080"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00637-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2010.06.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.183582"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605213200"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.144287"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature719"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00652-9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176344136"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00753-0"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02732"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio862"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M610485200"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0303329101"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01013-9"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2011.216523","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2011.216523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T07:40:01Z","timestamp":1698738001000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2011.216523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,14]]},"references-count":20,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2011,10,15]]}},"alternative-id":["10.1113\/jphysiol.2011.216523"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2011.216523","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,14]]}}}