{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:55:06Z","timestamp":1791330906336,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,3,14]],"date-time":"2012-03-14T00:00:00Z","timestamp":1331683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2012,4,15]]},"abstract":"<jats:p><jats:bold>Key points\u2002<\/jats:bold> <jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Healthy sedentary ageing leads to stiffening of the heart; however, when this process occurs during ageing has been unknown.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In this study, 70 healthy sedentary subjects were stratified into four groups: \u2018young\u2019\u2013 G<jats:sub>21\u221234<\/jats:sub>: 21\u201334 years; \u2018early middle\u2010age\u2019\u2013 G<jats:sub>35\u221249<\/jats:sub>: 35\u201349 years; \u2018late middle\u2010age\u2019\u2013 G<jats:sub>50\u221264<\/jats:sub>: 50\u201364 years; and \u2018seniors\u2019\u2013 G<jats:sub>\u226565<\/jats:sub>: \u226565 years.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Invasive catheter measurements showed a substantially greater left ventricular (LV) compliance (more flexible\/less stiff) in G<jats:sub>21\u221234<\/jats:sub> than G<jats:sub>50\u221264<\/jats:sub> and G<jats:sub>\u226565<\/jats:sub>.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Although LV chamber compliance in G<jats:sub>50\u221264<\/jats:sub> and G<jats:sub>\u226565<\/jats:sub> appeared identical, pressure\u2013volume curves were shifted leftward, exhibiting a smaller volume for any given pressure with increasing age.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our results suggest that LV stiffening with ageing occurs during the transition between youth and middle\u2010age and becomes manifest between the ages of 50\u201364; LV volume contraction and remodelling follow in the senior years. 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