{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:59:58Z","timestamp":1790830798393,"version":"4.1.0"},"reference-count":78,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T00:00:00Z","timestamp":1323820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2011,12,15]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold>The thyroid hormones thyroxine (T<jats:sub>4<\/jats:sub>) and triiodothyronine (T<jats:sub>3<\/jats:sub>) play key roles in regulating development, growth and metabolism in pre\u2010 and postnatal life. Iodide (I<jats:sup>\u2212<\/jats:sup>) is an essential component of the thyroid hormones and is accumulated avidly by the thyroid gland. The rarity of elemental iodine and I<jats:sup>\u2212<\/jats:sup>in the environment challenges the thyroid to orchestrate a remarkable series of transport processes that ultimately ensure sufficient levels for hormone synthesis. In addition to actively extracting circulating I<jats:sup>\u2212<\/jats:sup>, thyroid follicular epithelial cells must also translocate I<jats:sup>\u2212<\/jats:sup>into a central intrafollicular compartment, where thyroglobulin is iodinated to form the protein precursor to T<jats:sub>4<\/jats:sub>and T<jats:sub>3<\/jats:sub>. In the last decade, several bodies of evidence render questionable the notion that I<jats:sup>\u2212<\/jats:sup>exits thyrocytes solely via the Cl<jats:sup>\u2212<\/jats:sup>\/I<jats:sup>\u2212<\/jats:sup>exchanger Pendrin (SLC26A4), therefore necessitating reconsideration of several other candidate I<jats:sup>\u2212<\/jats:sup>conduits: the Cl<jats:sup>\u2212<\/jats:sup>\/H<jats:sup>+<\/jats:sup>antiporter, CLC\u20105, the cystic fibrosis transmembrane conductance regulator (CFTR) and the sodium monocarboxylic acid transporter (SMCT1).<\/jats:p>","DOI":"10.1113\/jphysiol.2011.218594","type":"journal-article","created":{"date-parts":[[2011,10,11]],"date-time":"2011-10-11T05:18:36Z","timestamp":1318310316000},"page":"5929-5939","source":"Crossref","is-referenced-by-count":52,"title":["Thyroid iodide efflux: a team 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