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It is well known that we adapt to moderately cold temperatures, i.e. the same temperature feels less cold over time, and the cooling effects of menthol also wear off with time, presumably due to the calcium\u2010dependent desensitization of TRPM8 activity. The membrane phospholipid phosphatidylinositol 4,5\u2010bisphosphate (PIP<jats:sub>2<\/jats:sub>) is known to be required for TRPM8 activity. Our data support a model for desensitization, in which calcium influx through TRPM8 activates a phospholipase C enzyme, which breaks down PIP<jats:sub>2<\/jats:sub>, leading to decreased channel activity.<\/jats:p>","DOI":"10.1113\/jphysiol.2011.220228","type":"journal-article","created":{"date-parts":[[2011,10,18]],"date-time":"2011-10-18T05:51:05Z","timestamp":1318917065000},"page":"6007-6027","source":"Crossref","is-referenced-by-count":79,"title":["Decrease in phosphatidylinositol 4,5\u2010bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels"],"prefix":"10.1113","volume":"589","author":[{"given":"Yevgen","family":"Yudin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Lukacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chike","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Rohacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.12.005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-141481"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3270545"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0890-04.2004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2006.05.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05910"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703420104"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.04.017"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807270200"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1973.36.2.325"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/S0021-9258(18)89630-2","article-title":"sn\u20101,2\u2010Dioctanoylglycerol. 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