{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:58:17Z","timestamp":1791295097083,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,6]],"date-time":"2012-01-06T00:00:00Z","timestamp":1325808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p>\n                    <jats:bold>Non\u2010technical summary\u2002<\/jats:bold>\n                    Mucin secretion in the lung is regulated by the soluble\u2002\n                    <jats:italic>N<\/jats:italic>\n                    \u2010ethylmaleimide\u2010sensitive factor attachment protein receptor (SNARE) exocytotic core, which has not been defined in airway goblet cells. In this study, the SNARE vesicle\u2010associated membrane protein 8 (VAMP8) was found to be expressed in human airway epithelial goblet cells. VAMP8 knockdown by RNA interference techniques reduced airway epithelial mucin secretion induced by PAR agonists, neutrophil elastase and ATP. Basal (non\u2010agonist elicited) mucin secretion was also reduced as a result of VAMP8 knockdown. Importantly, mucin secretion was reduced in the lungs of VAMP8 knockout mice compared to wild\u2010type littermates. Our data suggest that VAMP8 is an essential SNARE in airway mucin granule exocytosis. Reduction of VAMP8 activity\/expression may provide a novel therapeutic target to ameliorate airway mucus obstruction in lung diseases.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2011.222091","type":"journal-article","created":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T20:40:36Z","timestamp":1323117636000},"page":"545-562","source":"Crossref","is-referenced-by-count":54,"title":["VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells"],"prefix":"10.1113","volume":"590","author":[{"given":"Lisa C.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama","family":"Moussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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