{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:54:17Z","timestamp":1778277257875,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T00:00:00Z","timestamp":1332806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2012,4,15]]},"abstract":"<jats:p><jats:bold>Key points\u2002<\/jats:bold> <jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>The anatomical structures and discrete nephric regions of the pronephric zebrafish kidney are similar to those of the mammalian nephron.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Renal blood supply and subsequent renal filtration rate are both key determinants of kidney function.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our study developed classical functional assays for larval zebrafish that effectively model the effects of the nephrotoxin gentamicin and high salt loading.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The techniques demonstrate the disruption in ion and water balance resulting from reduced cardiovascular flow and renal filtration rate.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The ability to measure cardio\u2010renal function in zebrafish offers advantages associated with the fish model to gain a wider understanding of kidney physiology.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1113\/jphysiol.2011.224352","type":"journal-article","created":{"date-parts":[[2012,2,14]],"date-time":"2012-02-14T03:41:25Z","timestamp":1329190885000},"page":"1803-1809","source":"Crossref","is-referenced-by-count":38,"title":["Techniques for the <i>in vivo<\/i> 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