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about the physiological roles of these purinoceptors regarding compartmentalization and selective activation, their contributions to the spatiotemporal properties of intracellular Ca<jats:sup>2+<\/jats:sup> signals and their roles in regulating protein exocytosis and ion channel activity.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In this study, we investigated the subtype\u2010specific sub\u2010cellular distribution and functional characterization of purinoceptors in mouse parotid acinar cells.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Selective activation of ionotropic purinergic receptor subtypes was shown to evoke spatially distinct cytosolic Ca<jats:sup>2+<\/jats:sup> signals as well as protein exocytosis.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This study identifies a subtype of ionotropic purinergic receptors as a potential therapeutic target for treatment of salivary gland hypofunction.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1113\/jphysiol.2012.228148","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T01:01:21Z","timestamp":1332810081000},"page":"2721-2737","source":"Crossref","is-referenced-by-count":15,"title":["Distinct contributions by ionotropic purinoceptor subtypes to ATP\u2010evoked calcium signals in mouse parotid acinar cells"],"prefix":"10.1113","volume":"590","author":[{"given":"Sumit","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas S.","family":"Verrill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristopher 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