{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:06:05Z","timestamp":1782486365229,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2012,5,15]]},"abstract":"<jats:p><jats:bold>Key points\u2002<\/jats:bold> <jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>When photoreceptors in vertebrate retina are exposed to bright light, a significant proportion of the photopigment in the rods can be bleached.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Bleaching produces a desensitization of the visual system that recovers slowly as pigment is slowly regenerated, by a process known as dark adaptation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Experiments on isolated amphibian rods have revealed some of the features of bleach\u2010induced desensitization, but such experiments have not so far been possible on mammals.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We now describe an improved method that makes possible the first direct measurements of pigment concentration and rod photoreceptor responses over a wide range of bleaching exposures from isolated cells or pieces of intact mammalian retina.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our experiments reveal important features of mammalian bleaching adaptation and will now make possible future studies from mouse animal lines containing genetically altered photoreceptor proteins.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1113\/jphysiol.2012.228627","type":"journal-article","created":{"date-parts":[[2012,3,27]],"date-time":"2012-03-27T01:01:21Z","timestamp":1332810081000},"page":"2353-2364","source":"Crossref","is-referenced-by-count":45,"title":["Bleaching of mouse rods: microspectrophotometry and suction\u2010electrode recording"],"prefix":"10.1113","volume":"590","author":[{"given":"S.","family":"Nymark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Frederiksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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