{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:19Z","timestamp":1791417619611,"version":"4.3.3"},"reference-count":57,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T00:00:00Z","timestamp":1338422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Processes leading to fatigue occur within the exercising muscle (peripheral fatigue) and the nervous system (central fatigue).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We asked whether central processes of fatigue would be increased after strenuous exercise in environments where oxygen availability is reduced (hypoxia) compared to the same absolute exercise intensity at sea\u2010level.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our main finding was that the contribution of central processes to fatigue was increased after exercise in hypoxia (equivalent to \u223c3800 m above sea\u2010level).<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The greater amount of central fatigue in hypoxia was due to suboptimal neural output from the brain and was associated with reductions in oxygen availability.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The findings provide a plausible mechanism for why exercise performance is impaired at high altitude, and might help our understanding of exercise limitation in patients with reduced oxygen delivery to the 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