{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:28:24Z","timestamp":1792171704635,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T00:00:00Z","timestamp":1344211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>High body temperature accompanies sleepiness, and loss of appetite and motivation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Suppression of orexin neurons has been suggested to be involved in such behavioural responses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>In this study we determined that orexin neurons are inhibited by an increase in temperature itself.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The effect of warming is mediated by a novel temperature sensing mechanism involving ATP\u2010sensitive potassium (KATP) channels.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>As KATP channels are also sensitive to energy balance, our results suggest that orexin neurons play an important role in regulating energy balance by inducing sickness behaviour when body temperature is elevated.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><jats:p><jats:bold>Abstract\u2002<\/jats:bold> High body temperatures are generally associated with somnolence, lethargy, hypophagia and anhedonia. Orexin neurons have been suggested to play a role in such sickness behaviours due to their known functions in appetite, behavioural and autonomic activation. Furthermore, the activity of orexin neurons is inhibited by lipopolysaccharide that induces fever. However, the cellular mechanism(s) underlying this suppression of orexin neurons was unknown. We used patch\u2010clamp recordings in acute rat brain slices to demonstrate that orexin neurons, including those projecting to the wake\u2010promoting locus coeruleus, are inhibited by increasing the ambient temperature by a 2\u20134\u00b0C increment between 26 and 40\u00b0C. This effect was not mediated by conventional thermosensing mechanisms but instead involved the activation of ATP\u2010sensitive potassium (KATP) channels. Since KATP channels can also sense energy substrate levels and cellular metabolism, our results suggest that orexin neurons can integrate the state of energy balance and body temperature, and adjust their output accordingly. Thus, the thermosensitivity of orexin neurons may be an important part of maintaining energy homeostasis during hyperthermia and fever.<\/jats:p>","DOI":"10.1113\/jphysiol.2012.236497","type":"journal-article","created":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T13:09:10Z","timestamp":1342530550000},"page":"4707-4715","source":"Crossref","is-referenced-by-count":11,"title":["ATP\u2010sensitive potassium channels mediate the thermosensory response of orexin neurons"],"prefix":"10.1113","volume":"590","author":[{"given":"Matthew 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