{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:12:12Z","timestamp":1790518332456,"version":"4.1.0"},"reference-count":65,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:00:00Z","timestamp":1367280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Fast spiking interneurons (FSIs) modulate output of the striatum and are implicated in severe motor disorders.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Selective expression of the calcium\u2010binding protein parvalbumin (PV) in FSIs raises questions about how PV controls FSI Ca<jats:sup>2+<\/jats:sup> dynamics.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Here we report a novel mechanism linking PV\u2010Ca<jats:sup>2+<\/jats:sup> buffering and FSI spiking as a result of the activation of small conductance (SK) Ca<jats:sup>2+<\/jats:sup>\u2010dependent K<jats:sup>+<\/jats:sup> channels.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>We also show that, at the presynaptic terminals, PV prevents synaptic facilitation at narrow frequencies at FSI to striatal output neuron synapses.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Our data establish that PV is a key element in providing rhythm generation in FSIs as well as filtering striatal output. Thus, FSI neuromodulation via PV and\/or SK channels is an interesting target for controlling the establishment of oscillatory frequencies related to the induction or worsening of pathology\u2010related motor rhythms.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><jats:p><jats:bold>Abstract\u2002<\/jats:bold> Striatal fast spiking interneurons (FSIs) modulate output of the striatum by synchronizing medium\u2010sized spiny neurons (MSNs). Recent studies have broadened our understanding of FSIs, showing that they are implicated in severe motor disorders such as parkinsonism, dystonia and Tourette syndrome. FSIs are the only striatal neurons to express the calcium\u2010binding protein parvalbumin (PV). This selective expression of PV raises questions about the functional role of this Ca<jats:sup>2+<\/jats:sup> buffer in controlling FSI Ca<jats:sup>2+<\/jats:sup> dynamics and, consequently, FSI spiking mode and neurotransmission. To study the functional involvement of FSIs in striatal microcircuit activity and the role of PV in FSI function, we performed perforated patch recordings on enhanced green fluorescent protein\u2010expressing FSIs in brain slices from control and PV\u2212\/\u2212 mice. Our results revealed that PV\u2212\/\u2212 FSIs fired more regularly and were more excitable than control FSIs by a mechanism in which Ca<jats:sup>2+<\/jats:sup> buffering is linked to spiking activity as a result of the activation of small conductance Ca<jats:sup>2+<\/jats:sup>\u2010dependent K<jats:sup>+<\/jats:sup> channels. A modelling approach of striatal FSIs supports our experimental results. Furthermore, PV deletion modified frequency\u2010specific short\u2010term plasticity at inhibitory FSI to MSN synapses. Our results therefore reinforce the hypothesis that in FSIs, PV is crucial for fine\u2010tuning of the temporal responses of the FSI network and for the orchestration of MSN populations. This, in turn, may play a direct role in the generation and pathology\u2010related worsening of motor rhythms.<\/jats:p>","DOI":"10.1113\/jphysiol.2012.250795","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T06:37:47Z","timestamp":1365057467000},"page":"3215-3232","source":"Crossref","is-referenced-by-count":87,"title":["Parvalbumin tunes spike\u2010timing and efferent short\u2010term plasticity in striatal fast spiking interneurons"],"prefix":"10.1113","volume":"591","author":[{"given":"David","family":"Orduz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don Patrick","family":"Bischop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Schwaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge 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